Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Key Laboratory of Heavy Ion Radiation Biology and Medicine, Chinese Academy of Sciences, Lanzhou 730000, China.
Int J Mol Sci. 2024 Jan 18;25(2):1175. doi: 10.3390/ijms25021175.
Mitochondria are double-membrane organelles that are involved in energy production, apoptosis, and signaling in eukaryotic cells. Several studies conducted over the past decades have correlated mitochondrial dysfunction with various diseases, including cerebral ischemia, myocardial ischemia-reperfusion, and cancer. Mitochondrial transplantation entails importing intact mitochondria from healthy tissues into diseased tissues with damaged mitochondria to rescue the injured cells. In this review, the different mitochondrial transplantation techniques and their clinical applications have been discussed. In addition, the challenges and future directions pertaining to mitochondrial transplantation and its potential in the treatment of diseases with defective mitochondria have been summarized.
线粒体是参与真核细胞能量产生、凋亡和信号转导的双层膜细胞器。过去几十年的几项研究表明，线粒体功能障碍与多种疾病有关，包括脑缺血、心肌缺血再灌注和癌症。线粒体移植涉及将完整的线粒体从健康组织导入有损伤线粒体的病变组织，以挽救受损细胞。本文综述了不同的线粒体移植技术及其临床应用。此外，还总结了线粒体移植所面临的挑战和未来方向及其在治疗有缺陷线粒体疾病中的潜在应用。
