Kadioglu Ates, Sanli Oner, Akman Tolga, Canguven Onder, Aydin Memduh, Akbulut Fatih, Kucukdurmaz Faruk
Department of Urology, Medical Faculty of Istanbul, Istanbul University, 34390 Capa, Istanbul, Turkey.
J Androl. 2011 Sep-Oct;32(5):502-8. doi: 10.2164/jandrol.110.011031. Epub 2011 Jan 13.
Only a few studies have investigated the association between the severity of Peyronie disease (PD) and clinical parameters such as age and associated comorbidities. The aim of this study was to report the relationship between the degree of curvature of the penis and the clinical parameters among patients with PD. A total of 1001 patients with PD were evaluated retrospectively in terms of penile deformity, erectile status, and risk factors for systemic vascular diseases. The degree of curvature was assessed with a protractor during maximum erection in response to a combined injection and stimulation test and/or vacuum device. A modified Kelami classification was used to categorize penile deformities as follows: patients with deformities without curvature (notching, hourglass, and swan neck deformity, group 1), with mild curvature (≤ 30 degrees, group 2), with moderate curvature (31-60 degrees, group 3), or with severe curvature (> 60 degrees, group 4). Chi-square tests, 1-way analysis of variance, and univariate and multiple ordinal regression analyses were used for statistical analysis. Penile deformity without curvature was detected in 12.3% of the patients, whereas the curvature was less than 30 degrees in 39.5%, 30 to 60 degrees in 34.5%, and more than 60 degrees in 13.5% of the patients. Multiple ordinal regression analysis identified age (P = .013), side of deformity (P = .007), erectile dysfunction (P < .0001), and diabetes mellitus (P = .001) as significant independent predictors of the severity of penile curvature. In conclusion, patients' age, side of deformity, erectile function, and diabetes were significantly associated with the degree of curvature.
仅有少数研究调查了佩罗尼氏病（PD）的严重程度与年龄及相关合并症等临床参数之间的关联。本研究的目的是报告PD患者阴茎弯曲程度与临床参数之间的关系。对总共1001例PD患者进行了回顾性评估，内容包括阴茎畸形、勃起状态以及全身血管疾病的危险因素。在联合注射和刺激试验及/或真空装置诱发的最大勃起状态下，使用量角器评估弯曲程度。采用改良的凯拉米分类法将阴茎畸形分为以下几类：无弯曲畸形（切口、沙漏形和天鹅颈畸形，第1组）、轻度弯曲（≤30度，第2组）、中度弯曲（31 - 60度，第3组）或重度弯曲（>60度，第4组）。采用卡方检验、单因素方差分析以及单变量和多变量有序回归分析进行统计分析。12.3%的患者检测到无弯曲的阴茎畸形，而39.5%的患者弯曲小于30度，34.5%的患者弯曲在30至60度之间，13.5%的患者弯曲大于60度。多变量有序回归分析确定年龄（P = 0.013）、畸形侧别（P = 0.007）、勃起功能障碍（P < 0.0001）和糖尿病（P = 0.001）是阴茎弯曲严重程度的显著独立预测因素。总之，患者的年龄、畸形侧别、勃起功能和糖尿病与弯曲程度显著相关。
