Laboratory of Environmental Toxicology, Department of Biological Sciences, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
J Occup Health. 2011;53(2):115-22. doi: 10.1539/joh.o10026. Epub 2011 Jan 11.
In Brazil, DDT was used to control malaria-transmitting mosquitoes from 1945 to 1997. Owing to concerns about the potential adverse health consequences of long-term exposures to DDT, workers of the National Foundation of Health (FNS) who had taken part in malaria control operations in the Amazon region were monitored for blood levels of DDT as well as for their health status between 1997 and 2001.
To evaluate blood levels of DDT/DDE and elimination half-life (t(1/2)) of pp'-DDE in malaria control personnel.
Levels of DDT and pp'-DDE were measured in the blood serum of 119 public health workers (32-67 yr old, 117 males) from Pará state-Brazil. Serum levels of DDT/DDE were determined by gas chromatography with electron capture detection.
Blood serum levels of -Σ-DDT and pp'-DDE (mean ± SD) were as follows (µg/l): February 1997 (N=110), 231.5 ± 366.4 (156.9 ± 236.8 as pp'-DDE); February 1998 (N=116), 126.4 ± 86.6 (83.0 ± 54.6 as pp'-DDE); May 2001 (N=117), 50.4 ± 53.3 (39.4 ± 37.6 as pp'-DDE). The half-life (mean ± SD) of pp'-DDE was 29.5 ± 22.7 mo.
Concentrations of Σ-DDT/ pp'-DDE in the blood serum of malaria control workers were much higher than levels found in the general population in Brazil and elsewhere. The half-life of pp'-DDE (29.5 mo) estimated for this group of occupationally exposed male adults was shorter than t(1/2) values previously reported for environmentally exposed subjects.
在巴西，1945 年至 1997 年期间，滴滴涕被用于控制传播疟疾的蚊子。由于担心长期接触滴滴涕可能对健康造成不利影响，国家卫生基金会（FNS）的工作人员曾参与亚马逊地区的疟疾控制行动，1997 年至 2001 年间，对他们的血液滴滴涕水平以及健康状况进行了监测。
评估疟疾控制人员血液中的滴滴涕/滴滴伊浓度以及对-pp’-滴滴伊的消除半衰期（t(1/2)）。
检测了巴西帕拉州 119 名公共卫生工作者（32-67 岁，男性 117 名）的血清中的滴滴涕和-pp’-滴滴伊水平。采用气相色谱法和电子俘获检测法测定血清中的滴滴涕/滴滴伊浓度。
1997 年 2 月（N=110）、1998 年 2 月（N=116）和 2001 年 5 月（N=117）血清中-Σ-DDT 和-pp’-滴滴伊的平均浓度（±SD）分别为：231.5±366.4μg/L（156.9±236.8μg/L 为 -pp’-滴滴伊）、126.4±86.6μg/L（83.0±54.6μg/L 为 -pp’-滴滴伊）和 50.4±53.3μg/L（39.4±37.6μg/L 为 -pp’-滴滴伊）。-pp’-滴滴伊的半衰期（mean ± SD）为 29.5±22.7 个月。
与巴西和其他地区的一般人群相比，疟疾控制工作者血清中的Σ-DDT/-pp’-滴滴伊浓度要高得多。本研究中，职业接触的成年男性个体的 -pp’-滴滴伊半衰期（29.5 个月）比以往报道的环境接触人群的半衰期短。
