Kamalakkannan Soundararajan, Rajendran Ramaswamy, Venkatesh Ramasamy V, Clayton Paul, Akbarsha Mohammad A
Department of Animal Science, Bharathidasan University, Tiruchirappalli 620 024, India.
J Nutr Metab. 2010;2010:285301. doi: 10.1155/2010/285301. Epub 2010 Dec 28.
There is evidence that the principles present in the widely consumed Indian food plant C. fimbriata extract (CFE) suppress appetite, and provide antiobesogenic and metabolic benefits. The Diet-Induced Obesity (DIO) rat model was used to investigate CFE's anorexigenic effects. Rats were randomly divided into three groups: (i) untreated control (C), (ii) control for cafeteria diet (CA), and (iii) cafeteria diet fed + CFE treated. Rats in the test group received cafeteria diet and CFE from day one onwards. CFE was administered by gavage at three doses (25, 50, 100 mg/Kg BW per day) for 90 days. The antiobesogenic effects of CFE were evaluated by monitoring changes in feed intake, body weight, serum lipid and hormonal (leptin) profiles, fat pads, and liver weight. Antiatherosclerotic effects were measured by histology. CFE induced significant and dose-dependent inhibition of food intake, with dose-related prevention of gains in body weight, liver weight, and fat pad mass. Alterations in serum lipid profiles associated with weight gain were similarly inhibited, as were the typical increases in serum leptin levels. These data substantiate CFE's reported anorexigenic effects. CFE treatment also conferred protection against atherogenesis. We conclude that CFE possesses antiobesogenic and antiatherosclerotic properties.
有证据表明，广泛食用的印度食用植物流苏番荔枝提取物（CFE）中的成分可抑制食欲，并具有抗肥胖和代谢益处。采用饮食诱导肥胖（DIO）大鼠模型来研究CFE的厌食作用。将大鼠随机分为三组：（i）未处理的对照组（C），（ii）自助餐饮食对照组（CA），以及（iii）自助餐饮食喂养+CFE处理组。测试组的大鼠从第一天起接受自助餐饮食和CFE。以三种剂量（每天25、50、100mg/Kg体重）通过灌胃给予CFE，持续90天。通过监测采食量、体重、血清脂质和激素（瘦素）水平、脂肪垫和肝脏重量的变化来评估CFE的抗肥胖作用。通过组织学测量抗动脉粥样硬化作用。CFE引起了显著的、剂量依赖性的食物摄入量抑制，以及与剂量相关的体重、肝脏重量和脂肪垫质量增加的预防。与体重增加相关的血清脂质水平变化同样受到抑制，血清瘦素水平的典型升高也受到抑制。这些数据证实了CFE所报道的厌食作用。CFE处理还赋予了对动脉粥样硬化形成的保护作用。我们得出结论，CFE具有抗肥胖和抗动脉粥样硬化特性。
