Krupina N A, Khlebnikova N N, Orlova I N, Grafova V N, Smirnova V S, Rodina V I, Kukushkin M L, Kryzhanovsky G N
Laboratory of Nervous System General Pathology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2010 Oct;149(4):479-84. doi: 10.1007/s10517-010-0975-3.
Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic pain syndrome augmented by some parameters the depressive symptoms and provoked manifestation of signs of depressive behavior in animals treated with saline.
通过对后肢坐骨神经预先交叉诱导出明显且逐渐发展的神经源性疼痛综合征的动物，给予亚慢性注射MPTP前体毒素来诱发实验性抑郁综合征，从而建立大鼠疼痛与抑郁的联合状态。神经源性疼痛综合征在某些参数上加重了抑郁症状，并在给予生理盐水治疗的动物中引发了抑郁行为迹象的表现。
