[Lymphatic tumors with monoclonal immunoglobulin secretion (clinical laboratory comparisons)].

Immunochemistry of proteins of blood serum and urine using novel highly sensitive methods (immunofixed electrophoresis and countercurrent isotachoimmunoelectrophoresis on acetate-cellulose membranes) was performed in 123 patients with lymphatic tumors. Of these, 85 patients had chronic lympholeukemia, 21 lymphocytoma, 9 lymphosarcoma and 8 Waldenström's macroglobulinemia. Monoclonal secretion was detected in 49.6% of the patients on the whole. Isolated secretion of BJ protein turned out to be dominant immunoglobulinopathy in all the clinical groups under study. However, it was observed more frequently in chronic lympholeukemia than in lymphocytomas and lymphosarcomas (respectively 58.4% against 23.8 and 22.2%). Detailed clinico-laboratory comparisons have demonstrated that the patterns of lymphatic tumors with isolated secretion of immunoglobulin L-chains differed from nonsecreting ones in worse prognosis.