人在酸性尿液条件下齐哌丙醇的血浆浓度及排泄情况。

Plasma concentrations and excretion of zipeprol in man under acidic urine conditions.

作者信息

Beckett A H, Achari R

出版信息

J Pharm Pharmacol. 1977 Oct;29(10):589-92. doi: 10.1111/j.2042-7158.1977.tb11411.x.

DOI:10.1111/j.2042-7158.1977.tb11411.x

Abstract

Plasma concentrations of zipeprol, and the urinary excretion of it and two of its basic metabolites, compound II and compound III were examined after oral administration of zipeprol hydrochloride to man. The drug was rapidly and extensively metabolized, and the amount of unchanged drug excreted in the acidic urine varied from 1-5% of the dose; the two basic metabolites accounted for 19-38% of the dose.

摘要

给人体口服盐酸齐哌丙醇后，检测了齐哌丙醇的血浆浓度及其两种碱性代谢产物化合物II和化合物III的尿液排泄情况。该药物迅速且广泛地被代谢，酸性尿液中排泄的未变化药物量占剂量的1 - 5%；两种碱性代谢产物占剂量的19 - 38%。