Division of Infectious Diseases, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Hematol Oncol Clin North Am. 2011 Feb;25(1):171-91. doi: 10.1016/j.hoc.2010.11.012.
The herpes viruses are responsible for a wide range of diseases in patients following transplant, resulting from direct viral effects and indirect effects, including tumor promotion. Effective treatments and prophylaxis exist for the neurotropic herpes viruses HSV-1, HSV-2, varicella zoster virus, and possibly HHV-6. Antivirals seem to be less effective at prevention of the tumor-promoting effects of Epstein-Barr virus and HHV-8. Reduction in immunosuppression is the cornerstone to treatment of many diseases associated with herpes virus infections.
疱疹病毒可导致移植术后患者发生多种疾病，其致病机制包括直接的病毒作用和间接作用，如促进肿瘤生长。目前已有针对神经嗜性疱疹病毒 HSV-1、HSV-2、水痘-带状疱疹病毒和可能的 HHV-6 的有效治疗和预防药物。抗病毒药物似乎对预防 EBV 和 HHV-8 的促肿瘤作用效果欠佳。减少免疫抑制是治疗许多与疱疹病毒感染相关疾病的基石。
