Department of Plant Sciences, University of Oxford, South Parks Road, OX1 3RB, Oxford, UK.
Curr Opin Microbiol. 2011 Feb;14(1):31-8. doi: 10.1016/j.mib.2010.12.008. Epub 2011 Jan 12.
The bacterial plant pathogen Pseudomonas syringae causes economically important diseases of a wide variety of plant species and is used as a model organism to understand the molecular basis of plant disease. Much existing research into P. syringae-plant interactions has focused on the molecular basis of plant disease resistance and the role of secreted effector proteins in the suppression of plant defences. However, researchers have speculated that the diverse array of effectors, toxins and hormones produced by this pathogen also play an important role in manipulating plant metabolism to promote infection. Recent advances in metabolomics, genomics, transcriptomics and metabolic modelling offer new opportunities to address this question and generate a system-level understanding of metabolic interactions at the host-pathogen interface.
植物病原菌丁香假单胞菌可引发多种植物物种的重要经济病害，被用作研究植物疾病分子基础的模式生物。丁香假单胞菌与植物相互作用的大量现有研究主要集中在植物抗病性的分子基础以及分泌效应蛋白在抑制植物防御方面的作用。然而，研究人员推测，这种病原体产生的多种效应物、毒素和激素也在操纵植物代谢以促进感染方面发挥着重要作用。代谢组学、基因组学、转录组学和代谢建模方面的最新进展为解决这一问题提供了新的机会，并使我们能够从系统层面理解宿主-病原体界面的代谢相互作用。
