Abulaiti Alimujiang, Hu Dayi, Zhu Danian, Zhang Runfeng
Cardiovascular Department, Armed Police Hospital of Xinjiang, No. 669 South Nanchang Road, 830091, Urumqi, China.
Heart Vessels. 2011 Nov;26(6):654-62. doi: 10.1007/s00380-010-0108-y. Epub 2011 Jan 15.
Electrical stimulation of the rostal cerebellar fastigial nucleus (FNS) has been proved to have neuroprotective effects, but it is not known whether FNS also has a cardioprotective effect. One hundred Sprague-Dawley rats were randomly allocated into four groups, including a sham-operation group (Sham group), rats whose coronary arteries were ligated but the FNs were sham stimulated (AMI group), rats in which both coronary arteries were ligated and FNs were stimulated (FNS group), and rats whose fastigial nuclei were lesioned 5 days before ligation, then their coronary arteries were ligated and FNs were stimulated (FNL group). Heart rate variability parameters were monitored 6 h, 24 h, 7 days and 21 days after ligation, and mortality rates, hemodynamic parameters and infarction sizes were compared after 21 days. FNS improved the survival of rats, and this may be due to the increased vagal and decreased sympathetic tone. FN stimulation does not affect infarction size and hemodynamic parameters. FN stimulation may have a protective effect on surgically induced myocardial infarction rats.
对延髓小脑顶核（FNS）进行电刺激已被证明具有神经保护作用，但FNS是否也具有心脏保护作用尚不清楚。将100只Sprague-Dawley大鼠随机分为四组，包括假手术组（假手术组）、冠状动脉结扎但FNs接受假刺激的大鼠（急性心肌梗死组）、冠状动脉结扎且FNs接受刺激的大鼠（FNS组），以及在结扎前5天损伤顶核，然后结扎冠状动脉并刺激FNs的大鼠（FNL组）。在结扎后6小时、24小时、7天和21天监测心率变异性参数，并在21天后比较死亡率、血流动力学参数和梗死面积。FNS提高了大鼠的存活率，这可能是由于迷走神经张力增加和交感神经张力降低。FN刺激不影响梗死面积和血流动力学参数。FN刺激可能对手术诱导的心肌梗死大鼠具有保护作用。
