Golanov E V, Reis D J
Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA.
Neurosci Lett. 1996 May 10;209(2):101-4. doi: 10.1016/0304-3940(96)12611-2.
We recorded neurons in rat cerebral cortex with activity relating to the neurogenic elevations in regional cerebral blood flow (rCBF) coupled to stereotyped bursts of EEG activity, burst-cerebrovascular wave complexes, appearing spontaneously or evoked by electrical stimulation of rostral ventrolateral medulla (RVL) or fastigial nucleus (FN). Of 333 spontaneously active neurons only 15 (5%), in layers 5-6, consistently (P < 0.05, chi-square) increased their activity during the earliest potential of the complex, approximately 1.3 s before the rise of rCBF, and during the minutes-long elevation of rCBF elicited by 10 s of stimulation of RVL or FN. The results indicate the presence of a small population of neurons in deep cortical laminae whose activity correlates with neurogenic elevations of rCBF. These neurons may function to transduce afferent neuronal signals into vasodilation.
我们记录了大鼠大脑皮层中的神经元活动，这些活动与局部脑血流（rCBF）的神经源性升高有关，rCBF的升高与脑电图活动的刻板爆发、爆发性脑血管波复合体相关，这些复合体可自发出现，或由延髓头端腹外侧区（RVL）或小脑顶核（FN）的电刺激诱发。在333个自发活动的神经元中，只有15个（5%）位于5-6层，在复合体最早的电位期间（大约在rCBF升高前1.3秒）以及由RVL或FN刺激10秒引起的长达数分钟的rCBF升高期间，其活动持续（P<0.05，卡方检验）增加。结果表明，在深层皮质板层中存在一小群神经元，其活动与rCBF的神经源性升高相关。这些神经元可能起到将传入神经信号转化为血管舒张的作用。
