Truelove J F, Tanner J R, Langlois I A, Stapley R A, Arnold D L, Mes J C
Toxicology Research Division, Bureau of Chemical Safety, Health and Welfare Canada, Ottawa, Ontario.
Arch Environ Contam Toxicol. 1990 Nov-Dec;19(6):939-43. doi: 10.1007/BF01055065.
Female rhesus monkeys (Macaca mulatta) ingested gelatin capsules containing daily doses of 0 (control), 5, 20, 40, or 80 micrograms of Aroclor 1254/kg/day (PCB) which was dissolved in corn oil plus glycerol. After approximately two years of dosing and when the monkeys were near an adipose tissue PCBs equilibrium, each dose group of 16 animals was randomly divided into two test groups. Daily blood samples from both groups were acquired for estrogen and progesterone analysis during one menstrual cycle. Test group 1 was sampled during February-March and test group 2 during August-September. Serum estrogen and progesterone concentrations in monkeys dosed with PCBs were equivalent to control values with the exception of the luteal phase progesterone levels in the 20 and 80 micrograms/kg/day dosed monkeys in test group 1. There was no difference in menstrual cycle length between control and treated monkeys for the month sampled, however, menses duration was marginally longer in the 80 micrograms/kg/day dose group. There were no apparent treatment related differences in the incidence of anovulatory cycles nor on the temporal relationship between the estrogen peak and menses onset, menses end or the progesterone peak.
雌性恒河猴（猕猴）摄入含有每日剂量为0（对照）、5、20、40或80微克/千克/天的艾氏剂1254（多氯联苯）的明胶胶囊，该多氯联苯溶解于玉米油加甘油中。给药约两年后，当猴子接近脂肪组织中多氯联苯平衡时，每组16只动物的每个剂量组被随机分为两个测试组。在一个月经周期内，从两组动物中每日采集血样进行雌激素和孕酮分析。测试组1在2月至3月采样，测试组2在8月至9月采样。除测试组1中剂量为20和80微克/千克/天的猴子在黄体期的孕酮水平外，多氯联苯给药猴子的血清雌激素和孕酮浓度与对照值相当。在采样月份，对照猴子和接受治疗猴子的月经周期长度没有差异，然而，80微克/千克/天剂量组的月经持续时间略长。在无排卵周期的发生率以及雌激素峰值与月经开始、月经结束或孕酮峰值之间的时间关系方面，没有明显的与治疗相关的差异。
