Müller W F, Hobson W, Fuller G B, Knauf W, Coulston F, Korte F
Ecotoxicol Environ Saf. 1978 Sep;2(2):161-72. doi: 10.1016/0147-6513(78)90007-6.
After the rhesus monkey was demonstrated to be a suitable model for man in both metabolic and endocrinological studies, effects of hexachlorobenzene (HCB) and polychlorinated biphenyls (PCB) on the pattern of sexual hormones in cycling female rhesus monkeys were investigated. After confirmed ovulation, four adult female rhesus monkeys were treated during the following cycle with 4 mg/kg/day of HCB, and four other monkeys were treated with the same dose of Clophen A 30. Ovulation was blocked in three PCB-treated and one HCB-treated monkeys. Whereas the levels of luteinizing hormone and follicle-stimulating hormone did not seem to be changed directly by the treatment, low estrogen levels were found during the anovulatory cycles. Studies with PCB- and HCB-treated superovulated rats indicated interaction of the chemicals with ovarian steroidogenesis. Altered hepatic steroid metabolism may also cause low estrogen levels in treated animals.
在恒河猴被证明是代谢和内分泌研究中适合人类的模型后，研究了六氯苯（HCB）和多氯联苯（PCB）对处于发情周期的雌性恒河猴性激素模式的影响。确认排卵后，在接下来的周期中，对四只成年雌性恒河猴每天给予4mg/kg的HCB进行治疗，另外四只猴子给予相同剂量的氯芬A 30进行治疗。在三只接受PCB治疗和一只接受HCB治疗的猴子中排卵被阻断。虽然促黄体生成素和促卵泡激素的水平似乎没有因治疗而直接改变，但在无排卵周期中发现雌激素水平较低。对接受PCB和HCB治疗的超排卵大鼠的研究表明，这些化学物质与卵巢类固醇生成存在相互作用。肝脏类固醇代谢的改变也可能导致治疗动物体内雌激素水平降低。
