School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
J Theor Biol. 2011 Apr 7;274(1):52-7. doi: 10.1016/j.jtbi.2011.01.014. Epub 2011 Jan 15.
Perivascular space (PVS) within the brain is an important pathway for interstitial fluid (ISF) and solute transport. Fluid flowing in the PVS can affect these transport processes and has significant impacts on physiology. In this paper, we carry out a theoretical analysis to investigate the fluid mechanics in the PVS. With certain assumptions and approximations, we are able to find an analytical solution to the problem. We discuss the physical meanings of the solution and particularly examine the consequences of the induced fluid flow in the context of convection-enhanced delivery (CED). We conclude that peristaltic motions of the blood vessel walls can facilitate fluid and solute transport in the PVS.
脑内的血管周围间隙（PVS）是细胞外液（ISF）和溶质转运的重要途径。在 PVS 中流动的液体可以影响这些转运过程，并对生理学产生重大影响。在本文中，我们进行了理论分析以研究 PVS 中的流体力学。通过某些假设和近似，我们能够找到该问题的解析解。我们讨论了解的物理意义，并特别在对流增强递送（CED）的背景下研究了诱导流的后果。我们的结论是，血管壁的蠕动运动可以促进 PVS 中的液体和溶质转运。
