Kelley Douglas H, Thomas John H
Department of Mechanical Engineering, University of Rochester, Rochester, New York, USA.
Department of Mechanical Engineering and Department of Physics and Astronomy, University of Rochester, Rochester, New York, USA.
Annu Rev Fluid Mech. 2023;55:237-264. doi: 10.1146/annurev-fluid-120720-011638. Epub 2022 Sep 28.
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and through the brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, and metabolic wastes. Passing through brain tissue primarily during sleep, this circulation has implications for neurodegenerative disorders including Alzheimer's disease, for tissue damage during stroke and cardiac arrest, and for flow-related disorders such as hydrocephalus and syringomyelia. Recent experimental results reveal several features of this flow, but other aspects are not fully understood, including its driving mechanisms. We review the experimental evidence and theoretical modeling of cerebrospinal fluid flow, including the roles of advection and diffusion in transporting solutes. We discuss both local, detailed fluid-dynamic models of specific components of the system and global hydraulic models of the overall network of flow paths.
脑脊液和间质液在中枢神经系统周围并穿过大脑的循环不仅运输那些似水的液体，还运输它们携带的任何溶质，包括营养物质、药物和代谢废物。这种循环主要在睡眠期间通过脑组织，对包括阿尔茨海默病在内的神经退行性疾病、中风和心脏骤停期间的组织损伤以及诸如脑积水和脊髓空洞症等与流动相关的疾病都有影响。最近的实验结果揭示了这种流动的几个特征，但其他方面尚未完全理解，包括其驱动机制。我们回顾了脑脊液流动的实验证据和理论模型，包括平流和扩散在溶质运输中的作用。我们讨论了系统特定组件的局部、详细的流体动力学模型以及整个流动路径网络的全局水力模型。
