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在兔模型中加速模拟光致变色折叠式眼内透镜 20 年的阳光暴露。

Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model.

机构信息

John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.

出版信息

J Cataract Refract Surg. 2011 Feb;37(2):378-85. doi: 10.1016/j.jcrs.2010.08.052.

DOI:10.1016/j.jcrs.2010.08.052
PMID:21241924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3033600/
Abstract

PURPOSE

To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure.

SETTING

John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

DESIGN

Experimental study.

METHODS

A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT IOL (n = 5) in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm(2) for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically.

RESULTS

The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up.

CONCLUSIONS

The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation.

摘要

目的

评估一种新型光致变色疏水性丙烯酸眼内透镜（IOL）在延长紫外线（UV）照射下的长期生物相容性和光致变色稳定性。

设置

美国犹他州盐湖城约翰·A·莫兰眼中心。

设计

实验研究。

方法

将 Matrix Aurium 光致变色 IOL 植入右眼，将无光致变色特性的 Matrix Acrylic IOL（n = 6）或单片 AcrySof Natural SN60AT IOL（n = 5）植入左眼 11 只新西兰兔。兔子每 8 小时暴露在 5 mW/cm(2)的 UV 光源下 3 小时，相当于每天 9 小时，并持续长达 12 个月。通过在右眼照射笔形紫外线光源，在裂隙灯检查中评估光致变色变化。在对兔子进行人道处死并取出眼球后，将研究和对照 IOL 取出并在体外进行紫外线暴露评估，并进行组织病理学研究。

结果

在模拟至少 20 年 UV 暴露的条件下，12 个月后，光致变色 IOL 与对照 IOL 一样具有生物相容性。体外评估证实了保留的光学特性，在暴露于 UV 光后 7 秒内观察到光致变色变化。在 12 个月的随访中，兔子眼睛出现了该模型中预期的临床和组织病理学变化。

结论

新型光致变色 IOL 仅在暴露于 UV 光下才会变黄。光致变色变化是可逆的、可重复的且随时间稳定。IOL 在长达 12 个月的加速 UV 暴露模拟下具有生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/05476ee2c3d4/nihms-261034-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/be62cc838832/nihms-261034-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/d22887e108c3/nihms-261034-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/d3a56a5ac3f2/nihms-261034-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/05476ee2c3d4/nihms-261034-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/be62cc838832/nihms-261034-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/d22887e108c3/nihms-261034-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/d3a56a5ac3f2/nihms-261034-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53c3/3033600/05476ee2c3d4/nihms-261034-f0005.jpg

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Blue light-filtering intraocular lenses: review of potential benefits and side effects.蓝光滤过型人工晶状体：潜在益处与副作用综述
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