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本文引用的文献

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HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.低氧诱导因子-1 介导肠道缺血再灌注损伤的致病炎症反应。
Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G833-43. doi: 10.1152/ajpgi.00065.2010. Epub 2010 Aug 5.
2
HIF-2alpha deletion promotes Kras-driven lung tumor development.缺氧诱导因子-2α 缺失促进 Kras 驱动的肺肿瘤发生。
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14182-7. doi: 10.1073/pnas.1001296107. Epub 2010 Jul 21.
3
Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice.HIF-1alpha 拮抗剂 PX-478 的治疗抑制了原位人小细胞肺癌和肺腺癌在小鼠中的进展和扩散。
J Thorac Oncol. 2010 Jul;5(7):940-9. doi: 10.1097/JTO.0b013e3181dc211f.
4
Human cancers converge at the HIF-2alpha oncogenic axis.人类癌症集中在 HIF-2alpha 致癌轴上。
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21306-11. doi: 10.1073/pnas.0906432106. Epub 2009 Dec 2.
5
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.吖啶黄可抑制缺氧诱导因子-1（HIF-1）二聚化、肿瘤生长和血管生成。
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17910-5. doi: 10.1073/pnas.0909353106. Epub 2009 Oct 1.
6
Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.缺氧诱导的肺泡上皮-间质转化需要线粒体活性氧和缺氧诱导因子1。
Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1120-30. doi: 10.1152/ajplung.00007.2009. Epub 2009 Oct 2.
7
Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma.小细胞肺癌活检组织中的缺氧诱导因子-1α和血管内皮生长因子
Lung. 2009 Sep-Oct;187(5):321-9. doi: 10.1007/s00408-009-9169-z. Epub 2009 Aug 26.
8
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.低氧诱导因子2α（HIF2α）与RAS协同作用促进小鼠肺癌发生。
J Clin Invest. 2009 Aug;119(8):2160-70. doi: 10.1172/jci38443.
9
Upregulation of hypoxia-inducible factor-1alpha mRNA and its clinical significance in non-small cell lung cancer.缺氧诱导因子-1α mRNA在非小细胞肺癌中的表达上调及其临床意义
J Thorac Oncol. 2009 Mar;4(3):284-90. doi: 10.1097/JTO.0b013e31819852d5.
10
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.靶向热休克蛋白90可通过阻断辐射诱导的缺氧诱导因子-1α稳定来克服肺癌细胞的耐药性。
Cancer Res. 2009 Feb 15;69(4):1624-32. doi: 10.1158/0008-5472.CAN-08-0505. Epub 2009 Jan 27.

HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.

作者信息

Shimoda Larissa A, Semenza Gregg L

机构信息

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

Am J Respir Crit Care Med. 2011 Jan 15;183(2):152-6. doi: 10.1164/rccm.201009-1393PP.

DOI:10.1164/rccm.201009-1393PP
PMID:21242594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3159088/
Abstract
摘要