HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.
作者信息
Shimoda Larissa A, Semenza Gregg L
机构信息
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
出版信息
Am J Respir Crit Care Med. 2011 Jan 15;183(2):152-6. doi: 10.1164/rccm.201009-1393PP.
Abstract
摘要
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Human cancers converge at the HIF-2alpha oncogenic axis.人类癌症集中在 HIF-2alpha 致癌轴上。
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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.吖啶黄可抑制缺氧诱导因子-1（HIF-1）二聚化、肿瘤生长和血管生成。
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17910-5. doi: 10.1073/pnas.0909353106. Epub 2009 Oct 1.
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Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1120-30. doi: 10.1152/ajplung.00007.2009. Epub 2009 Oct 2.
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Lung. 2009 Sep-Oct;187(5):321-9. doi: 10.1007/s00408-009-9169-z. Epub 2009 Aug 26.
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HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.低氧诱导因子2α（HIF2α）与RAS协同作用促进小鼠肺癌发生。
J Clin Invest. 2009 Aug;119(8):2160-70. doi: 10.1172/jci38443.
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Upregulation of hypoxia-inducible factor-1alpha mRNA and its clinical significance in non-small cell lung cancer.缺氧诱导因子-1α mRNA在非小细胞肺癌中的表达上调及其临床意义
J Thorac Oncol. 2009 Mar;4(3):284-90. doi: 10.1097/JTO.0b013e31819852d5.
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