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Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies.

作者信息

Dan Andra, Burtavel Livia-Malina, Coman Madalin-Codrut, Focsa Ina-Ofelia, Duta-Ion Simona, Juganaru Ioana-Ruxandra, Zaruha Andra-Giorgiana, Codreanu Patricia-Christina, Strugari Irina-Maria, Hotinceanu Iulian-Andrei, Bohiltea Laurentiu-Camil, Radoi Viorica-Elena

机构信息

Department of Medical Genetics, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

"Alessandrescu-Rusescu" National Institute for Maternal and Child Health, 20382 Bucharest, Romania.

出版信息

Cancers (Basel). 2024 Dec 2;16(23):4048. doi: 10.3390/cancers16234048.

DOI:10.3390/cancers16234048
PMID:39682234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11639944/
Abstract

Lung cancer, a malignant neoplasm originating from the epithelial cells of the lung, is characterized by its aggressive growth and poor prognosis, making it a leading cause of cancer-related mortality globally [...].

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/6214586aff5b/cancers-16-04048-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/0a6d0efbc6cc/cancers-16-04048-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c67b78cb8e61/cancers-16-04048-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/9b271c2a4852/cancers-16-04048-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/2ec7d4ae9af0/cancers-16-04048-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/0aaf0319f2a6/cancers-16-04048-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/6a984273375f/cancers-16-04048-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c89311c4c292/cancers-16-04048-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/a47b7d7afbce/cancers-16-04048-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/3acb3b9decac/cancers-16-04048-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/9ff98bb11b6c/cancers-16-04048-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/4ffe8f830d7f/cancers-16-04048-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c00b8fb595d7/cancers-16-04048-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/7c033599ae04/cancers-16-04048-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/099513b18fd3/cancers-16-04048-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/edfb3b72f9b3/cancers-16-04048-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/6214586aff5b/cancers-16-04048-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/0a6d0efbc6cc/cancers-16-04048-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c67b78cb8e61/cancers-16-04048-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/9b271c2a4852/cancers-16-04048-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/2ec7d4ae9af0/cancers-16-04048-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/0aaf0319f2a6/cancers-16-04048-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/6a984273375f/cancers-16-04048-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c89311c4c292/cancers-16-04048-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/a47b7d7afbce/cancers-16-04048-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/3acb3b9decac/cancers-16-04048-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/9ff98bb11b6c/cancers-16-04048-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/4ffe8f830d7f/cancers-16-04048-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/c00b8fb595d7/cancers-16-04048-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/7c033599ae04/cancers-16-04048-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/099513b18fd3/cancers-16-04048-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/edfb3b72f9b3/cancers-16-04048-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b47/11639944/6214586aff5b/cancers-16-04048-g016.jpg

相似文献

[1]
Genetic Blueprints in Lung Cancer: Foundations for Targeted Therapies.

Cancers (Basel). 2024-12-2

[2]
Transitioning to a Personalized Approach in Molecularly Subtyped Small-Cell Lung Cancer (SCLC).

Int J Mol Sci. 2024-4-10

[3]
Cancer genomics of lung cancer including malignant mesothelioma: A brief overview of current status and future prospects.

Adv Biol Regul. 2020-12

[4]
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[5]
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Biomarkers. 2024-7

[6]
Neuroendocrine Transformation as a Mechanism of Resistance to Targeted Lung Cancer Therapies: Emerging Mechanisms and Their Therapeutic Implications.

Cancers (Basel). 2025-1-15

[7]
Accurate treatment of small cell lung cancer: Current progress, new challenges and expectations.

Biochim Biophys Acta Rev Cancer. 2022-9

[8]
ALK-EML4 Fusion in Small Cell Lung Cancer: Clinical and Molecular Insights From a Rare Case.

Lung Cancer. 2025-4

[9]
Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer.

Am J Pathol. 2009-9

[10]
Whole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non-Small Cell Lung Cancers.

Cancer Med. 2025-4

本文引用的文献

[1]
The role of Keap1-Nrf2 signaling pathway in the treatment of respiratory diseases and the research progress on targeted drugs.

Heliyon. 2024-9-3

[2]
TGF-β and RAS jointly unmask primed enhancers to drive metastasis.

Cell. 2024-10-31

[3]
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers.

Cancers (Basel). 2024-8-20

[4]
Liquid biopsy for early detection of lung cancer.

Chin Med J Pulm Crit Care Med. 2023-10-20

[5]
Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions.

J Clin Med. 2024-7-18

[6]
Apoptotic signaling pathways in bone metastatic lung cancer: a comprehensive analysis.

Discov Oncol. 2024-7-26

[7]
Targeting apoptotic pathways for cancer therapy.

J Clin Invest. 2024-7-15

[8]
Biological and therapeutic implications of the cancer-related germline mutation landscape in lung cancer.

Lancet Respir Med. 2024-12

[9]
Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer.

J Transl Med. 2024-6-13

[10]
Oncofusions - shaping cancer care.

Oncologist. 2025-1-17

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