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退行性腰椎滑脱伴 L5-S1 椎间盘退变的手术疗效:至少 5 年随访的腰椎游离融合与腰骶融合的比较。

Surgical outcomes of degenerative spondylolisthesis with L5-S1 disc degeneration: comparison between lumbar floating fusion and lumbosacral fusion at a minimum 5-year follow-up.

机构信息

Department of Orthopedics Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

出版信息

Spine (Phila Pa 1976). 2011 Sep 1;36(19):1600-7. doi: 10.1097/BRS.0b013e3181f99e11.

Abstract

STUDY DESIGN

A retrospective clinical and radiographic study was performed.

OBJECTIVE

The purpose of this study was to compare outcomes of patients with degenerative spondylolisthesis and a preexisting degenerative L5-S1 disc treated with a lumbar floating fusion (LFF) versus lumbosacral fusion (LSF).

SUMMARY OF BACKGROUND DATA

Fusion for treatment of degenerative spondylolisthesis often ends at the L5 level. These patients usually had a preexisting L5-S1 disc degeneration; however, no literature mentions the role of prophylactic LSF in degenerative spondylolisthesis associated with L5-S1 disc degeneration.

METHODS

A total of 107 patients with a minimum 5-year follow-up who had lumbosacral or LFF with pedicle instrumentation for degenerative spondylolisthesis were included. UCLA (University of California, Los Angeles) classification was used to evaluate the radiographic results of the L5-S1 segment. The Oswestry Disability Index (ODI) and modified Brodsky's criteria were used to evaluate patients' clinical results. The incidence of adjacent segment disease (ASD) (includes radiographic and clinical ASD) of both ends was recorded.

RESULTS

There were no statistically significant differences in sex, age distribution, or amount of follow-up between the LFF and LSF groups. The LSF group had a higher percentage of patients that underwent total L5 laminectomy with loss of L5-S1 posterior ligament integrity (LSF = 92% vs. LFF = 67%, P = 0.019). The higher incidence of cephalic ASD in the LSF group was statistically significant (LSF = 25% vs. LFF = 9.7%, P = 0.049). Although no patient in the LSF group developed L5-S1 ASD, need for L5-S1 segment revision surgery was not prevented with LSF. Clinical outcomes on the basis of the success rate (LFF = 85.5% vs.LSF = 70.8%, P = 0.103) and ODI difference (LFF = 28.97 ± 15.82 vs. LSF = 23.04 ± 10.97, P = 0.109), there were no statistically significant difference between these two groups.

CONCLUSION

Posterior instrumentation with posterolateral LFF for the treatment of degenerative spondylolisthesis with concomitant L5-S1 disc degeneration results in a high percentage of satisfactory clinical results. Extended fusion to the sacrum did not provide a better clinical result. LSF could not reduce the incidence of revision surgery at the L5-S1 segment and involved greater incidence of cephalic ASD.

摘要

研究设计

回顾性临床和影像学研究。

目的

本研究旨在比较退行性脊椎滑脱症伴术前退行性 L5-S1 椎间盘病变患者接受腰椎浮动融合术(LFF)与腰骶融合术(LSF)治疗的结果。

背景资料总结

治疗退行性脊椎滑脱症的融合术通常止于 L5 水平。这些患者通常有术前 L5-S1 椎间盘退变;然而,没有文献提及预防性 LSF 在退行性脊椎滑脱症合并 L5-S1 椎间盘退变中的作用。

方法

共纳入 107 例接受后路腰椎或 LFF 加椎弓根内固定治疗退行性脊椎滑脱症的患者,随访时间至少 5 年。采用加利福尼亚大学洛杉矶分校(UCLA)分类法评估 L5-S1 节段的影像学结果。采用 Oswestry 功能障碍指数(ODI)和改良 Brodsky 标准评估患者的临床结果。记录两端相邻节段疾病(ASD)(包括影像学和临床 ASD)的发生率。

结果

LFF 组和 LSF 组在性别、年龄分布和随访时间方面无统计学差异。LSF 组行全 L5 椎板切除术且 L5-S1 后韧带完整性丧失的患者比例较高(LSF = 92% vs. LFF = 67%,P = 0.019)。LSF 组颅侧 ASD 的发生率较高,具有统计学意义(LSF = 25% vs. LFF = 9.7%,P = 0.049)。尽管 LSF 组无患者发生 L5-S1 ASD,但 LSF 并不能预防 L5-S1 节段翻修手术的需要。基于成功率(LFF = 85.5% vs. LSF = 70.8%,P = 0.103)和 ODI 差值(LFF = 28.97 ± 15.82 vs. LSF = 23.04 ± 10.97,P = 0.109),这两组之间无统计学差异。

结论

对于退行性脊椎滑脱症伴 L5-S1 椎间盘退变的患者,后路腰椎加后外侧 LFF 固定可获得较高比例的满意临床结果。向骶骨延伸融合并不能提供更好的临床结果。LSF 不能降低 L5-S1 节段翻修手术的发生率,反而会增加颅侧 ASD 的发生率。

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