Institute of Marine Biochemistry-VAST, Hanoi, Vietnam.
Planta Med. 2011 Jun;77(9):951-4. doi: 10.1055/s-0030-1250683. Epub 2011 Jan 17.
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and paulownin. The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities.
从 Palatiferum palatiferum 的根部分离得到两种新的木脂素，即 palatiferin A（1）和 palatiferin B（2），此外还分离得到了 5 种已知的三萜类化合物，分别为 epifriedelanol（3）、羽扇豆醇（4）、羽扇豆酮（5）、白桦脂醇（6）、齐墩果酸（7）和二肽 asperglaucide（8）。根据 2D-NMR 和质谱确定了它们的结构。根据与结构相似的化合物如 wodeshiol 和 paulownin 的旋光活性比较，提出了 1 和 2 的绝对构型。新的木脂素 palatiferin A（1）和 palatiferin B（2）对 KB 和 HepG2 细胞系表现出中等的细胞毒性。然而，白桦脂醇和羽扇豆醇是 Palatiferum palatiferum 根部分离得到的两种丰富的化合物，表现出细胞毒性和抗菌活性。
