Choi Sang Zin, Yang Min Cheol, Choi Sang Un, Lee Kang Ro
Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Arch Pharm Res. 2006 Mar;29(3):203-8. doi: 10.1007/BF02969394.
The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), 1beta-hydroperoxygermacra-4(15),5,10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds 1 approximately 4 and 8 showed non-specific significant cytotoxicity against five human tumor cell lines with ED50 values ranging from 0.36 approximately 5.54 microg/mL.
对窄头兔儿风（菊科）根的甲醇提取物进行色谱分离，得到了6个已知萜类化合物和2个已知木脂素。通过光谱方法确定它们的结构分别为莫克内酯（1）、桦木酮酸（2）、桦木酸（3）、扎鲁扎宁C（4）、1β-氢过氧化吉马-4(15),5,10(14)-三烯（5）、雨久花醇（6）、(+)-紫丁香树脂醇（7）和葡糖扎鲁扎宁C（8）。化合物1至4和8对5种人类肿瘤细胞系显示出非特异性的显著细胞毒性，半数有效剂量（ED50）值范围为0.36至5.54微克/毫升。
