Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Nat Prod Res. 2020 Feb;34(3):359-368. doi: 10.1080/14786419.2018.1533828. Epub 2019 Jan 2.
Phytochemical investigation of the roots of L. resulted in the isolation of ten terpenes and sixteen lignans, including a new triterpene saponin, officinoterpenoside E () and twenty-five known compounds (). All compounds were firstly isolated from except , , , . The structures of these compounds were determined by 1 D and 2 D NMR spectra referring to the literatures, together with high-resolution mass spectrometric analysis. All compounds were evaluated for the cytotoxicity against three cancer cell lines (HepG2, Hela, and MCF-7) . The results showed that compounds , , , and exhibited moderate cytotoxicity against HepG2, Hela and MCF-7 cells with IC values in the range of 16.8 ± 1.7 to 29.1 ± 1.9 μM. Therefore, these terpenoids and lignans may have potential biological activity, and also seemed to be of great chemotaxonomic value for .
对 L. 的根进行的植物化学研究导致分离出了十种萜类化合物和十六种木脂素，包括一种新的三萜皂苷 officinoterpenoside E () 和二十五种已知化合物 ()。除了 、 、 、 之外，所有化合物均首次从 中分离得到。这些化合物的结构通过参考文献的 1D 和 2D NMR 光谱以及高分辨率质谱分析确定。所有化合物均针对三种癌细胞系（HepG2、Hela 和 MCF-7）进行了细胞毒性评估。结果表明，化合物 、 、 、 和 对 HepG2、Hela 和 MCF-7 细胞具有中等细胞毒性，IC 值范围为 16.8 ± 1.7 至 29.1 ± 1.9 μM。因此，这些萜类化合物和木脂素可能具有潜在的生物活性，并且对于 似乎也具有重要的化学分类学价值。
