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1985 - 1988年埃及血吸虫病防治进展

Progress in the control of schistosomiasis in Egypt 1985-1988.

作者信息

Webbe G, el Hak S

机构信息

London School of Hygiene and Tropical Medicine, UK.

出版信息

Trans R Soc Trop Med Hyg. 1990 May-Jun;84(3):394-400. doi: 10.1016/0035-9203(90)90334-b.

Abstract

Continuing epidemiological evaluation of schistosomiasis intervention measures applied in Middle and Upper Egypt since 1985 indicate that a large measure of control of Schistosoma haematobium has been achieved in relation to both prevalence and intensity of the infection and incidence of new infections. Transmission control has, however, been inadequate in many areas, since numerous re-infections occurred in treated schoolchildren. Variable compliance rates in the chemotherapy delivery system were probably, in part, an important contributory factor, and short-comings of the selective and/or focal mollusciciding strategy were also probably responsible for many new cases and re-infections. Chemotherapy delivery has now been improved following the introduction of single dose treatments with praziquantel and it is expected that there will be an increased demand for treatment following the introduction of a new information-education-communication campaign. In communities with geometric mean egg-output of less than 50 per 10 ml of urine, acceptable control of the potential for development of schistosomal disease can be expected. It is concluded, therefore, that the future maintenance control strategy in this project area may call for more frequent chemotherapy treatments in identified foci of high prevalence and intensity, with complementary focal mollusciciding and/or targeted treatment of schoolchildren, in order to prevent the serious consequences of infection. In 1988 the annual cost of schistosomiasis control measures per person throughout the project area (2 million irrigated feddans (c .800,000 hectares] containing 12 million people) was 0.5 Egyptian pounds (LE) (US$ 0.20), representing 5.2% of the annual expenditure per person in Egypt (LE 9.6) for all health services.

摘要

自1985年以来,对埃及中上游地区应用的血吸虫病干预措施进行的持续流行病学评估表明,在感染率、感染强度和新感染发病率方面,埃及血吸虫病已实现了很大程度的控制。然而,许多地区的传播控制并不充分,因为接受治疗的学童中出现了大量再次感染的情况。化疗给药系统中不同的依从率可能在一定程度上是一个重要的促成因素,选择性和/或局部灭螺策略的缺陷也可能是许多新病例和再次感染的原因。随着吡喹酮单剂量治疗的引入,化疗给药现已得到改善,预计在开展新的信息教育宣传活动后,治疗需求将会增加。在每10毫升尿液中虫卵几何平均输出量低于50个的社区,可以预期对血吸虫病发展可能性的控制是可接受的。因此得出结论,该项目地区未来的维持控制策略可能需要在已确定的高流行率和高强度感染疫点更频繁地进行化疗,并辅以局部灭螺和/或对学童进行有针对性的治疗,以防止感染带来的严重后果。1988年,整个项目地区(200万灌溉费丹(约80万公顷),有1200万人)每人的血吸虫病控制措施年度成本为0.5埃及镑(0.20美元),占埃及每人所有卫生服务年度支出(9.6埃及镑)的5.2%。

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