Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
J Org Chem. 2011 Feb 18;76(4):1159-62. doi: 10.1021/jo102148p. Epub 2011 Jan 18.
Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
油和粘性液体的绝对立体化学很难确定。共结晶涉及生成由一种以上中性化合物组成的结晶物质。共结晶与 X 射线衍射和手性 HPLC 的结合在克服一系列手性 3-芳基丁酸的这些困难方面特别有效。与盐形成相比，共结晶具有优势，因为共晶在溶液中解离，这意味着可以使用相同的 HPLC 条件来分析感兴趣的物质及其共晶。
