Department of Paediatrics, Sahlgrenska Academy at University of Gothenburg, Sweden.
Acta Paediatr. 2011 May;100(5):676-9. doi: 10.1111/j.1651-2227.2011.02164.x. Epub 2011 Feb 14.
To evaluate the accuracy in transcutaneous (Tc) blood gas monitoring in newborn infants, including extremely low birth weight infants, during neonatal intensive care.
Tc PO(2) /PCO(2) was monitored in the neonatal intensive care unit (NICU) during stable infant conditions. In comparison, simultaneous arterial PO(2) and PCO(2) was measured. Sixty measurements were taken in 46 infants with median (range) birth weight of 0.93 (0.53-4.7) kg and at median (range) age of 8.5 (1-44) days. Comparison of measurements was performed using Bland-Altman plots, and the mean (95% CI) of the difference was calculated. Comparison was also performed in relation to body weight, postnatal age and oxygen requirement.
The mean (95% CI) difference in PO(2) (TcPO(2)-aPO(2)) was 0.3 (-0.2-0.9) kPa, and the corresponding difference in PCO(2) (TcPCO(2)-aPCO(2)) was 0.4 (0.03-0.8, p < 0.05) kPa. Some differences were related to body weight, age and oxygen requirement, but these differences were small.
There was good agreement between TcPO(2)/TcPCO(2) and corresponding arterial measurements. The mean difference between the methods was small and clinically acceptable in a current NICU. Tc blood gas monitoring could be recommended as a valuable complement for blood gas monitoring also in extremely low birth weight infants.
评估经皮（Tc）血气监测在新生儿重症监护中的准确性，包括极低出生体重儿。
在新生儿重症监护病房（NICU）中，在婴儿稳定的情况下监测 Tc PO₂/PCO₂。同时，测量动脉 PO₂ 和 PCO₂。对 46 名出生体重中位数（范围）为 0.93（0.53-4.7）kg、出生后中位数（范围）年龄为 8.5（1-44）天的婴儿进行了 60 次测量。使用 Bland-Altman 图比较测量值，并计算差值的平均值（95%CI）。还比较了体重、出生后年龄和氧需求与测量值的关系。
PO₂（TcPO₂-aPO₂）的平均（95%CI）差值为 0.3（-0.2-0.9）kPa，PCO₂（TcPCO₂-aPCO₂）的相应差值为 0.4（0.03-0.8，p<0.05）kPa。一些差异与体重、年龄和氧需求有关，但这些差异很小。
TcPO₂/TcPCO₂ 与相应动脉测量值之间具有良好的一致性。两种方法之间的平均差异较小，在当前的 NICU 中具有临床可接受性。Tc 血气监测可作为动脉血气监测的有价值补充，也可用于极低出生体重儿。
