MacGowan A P, Holt H A, Bywater M J, Reeves D S
Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK.
Eur J Clin Microbiol Infect Dis. 1990 Oct;9(10):767-70. doi: 10.1007/BF02184692.
The MICs and MBCs of 21 antimicrobial agents were determined for 103 strains of Listeria monocytogenes isolated in the UK and 27 strains of other Listeria species. Ampicillin, penicillin, azlocillin, imipenem, gentamicin, netilmicin, amikacin, erythromycin, rifampicin, trimethoprim, clindamycin and vancomycin had good activity, while cephalothin, chloramphenicol, ciprofloxacin and ofloxacin were less active, and cefuroxime, enoxacin, norfloxacin and fosfomycin were the least active. Tetracycline had good activity against many strains, but the MIC was high for some. Unlike the other Listeria species tested, Listeria ivanovii was susceptible to fosfomycin. Inoculum size and media employed were shown to affect the MBC, tryptose phosphate broth yielding higher MBCs than Mueller-Hinton or Isosensitest broths.
对从英国分离出的103株单核细胞增生李斯特菌和27株其他李斯特菌属菌株测定了21种抗菌剂的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。氨苄西林、青霉素、阿洛西林、亚胺培南、庆大霉素、奈替米星、阿米卡星、红霉素、利福平、甲氧苄啶、克林霉素和万古霉素具有良好活性，而头孢噻吩、氯霉素、环丙沙星和氧氟沙星活性较低，头孢呋辛、依诺沙星、诺氟沙星和磷霉素活性最低。四环素对许多菌株具有良好活性，但对一些菌株的MIC较高。与所测试的其他李斯特菌属不同，伊氏李斯特菌对磷霉素敏感。接种量和所用培养基显示会影响MBC，胰蛋白胨磷酸盐肉汤产生的MBC高于穆勒-欣顿肉汤或异源敏感性肉汤。
