Horai Yoshiro, Miyamura Tomoya, Shimada Karin, Takahama Soichiro, Minami Rumi, Yamamoto Masahiro, Suematsu Eiichi
Department of Internal Medicine and Rheumatology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, Japan.
Intern Med. 2011;50(2):151-4. doi: 10.2169/internalmedicine.50.4385. Epub 2011 Jan 15.
A 46-year-old female with a past history of ulcerative colitis (UC) was diagnosed with subacute thyroiditis (SAT), which improved with prednisolone (PSL) treatment (60 mg/day). The dose of PSL was gradually decreased, however upper back and neck pain and chest discomfort developed. The patient was diagnosed with Takayasu's arteritis (TA) based on wall thickening and luminal narrowing of the left common carotid artery and the left subclavian artery. The result of human leukocyte antigen typing analysis was A24 and B52 positive. These findings suggested that common genetic factors may be important for the etiology of TA, UC and SAT. This is the first report of TA that developed following UC and SAT.
一名有溃疡性结肠炎（UC）病史的46岁女性被诊断为亚急性甲状腺炎（SAT），经泼尼松龙（PSL）治疗（60毫克/天）后病情好转。PSL剂量逐渐减少，但患者出现了上背部和颈部疼痛以及胸部不适。根据左颈总动脉和左锁骨下动脉的管壁增厚和管腔狭窄，该患者被诊断为大动脉炎（TA）。人类白细胞抗原分型分析结果显示A24和B52呈阳性。这些发现表明，共同的遗传因素可能对TA、UC和SAT的病因学具有重要意义。这是首例在UC和SAT之后发生TA的报告。
