Division of Thoracic Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Curr Opin Cardiol. 2011 Mar;26(2):113-7. doi: 10.1097/HCO.0b013e3283439888.
Ischemic mitral regurgitation (IMR) is a major source of morbidity and mortality. Although mitral valve repair has become recently popularized for the treatment of IMR, select patients may derive benefits from replacement. The purpose of this review is to describe current surgical options for IMR and to discuss when mitral valve replacement (MVR) may be favored over mitral valve repair.
Current surgical options for the treatment of IMR include surgical revascularization alone, mitral valve repair, or MVR. Although surgical revascularization alone may benefit patients with mild-moderate IMR, most surgeons advocate the performance of revascularization in combination with either mitral valve repair or replacement. In the current era, mitral valve repair has proven to offer improved short-term and long-term survival, decreased valve-related morbidity, and improved left ventricular function compared with MVR. However, MVR should be considered for high-risk patients and those with specific underlying mechanisms of IMR.
In the absence of level one evidence, mitral valve repair offers an effective and durable surgical approach to the treatment of mitral insufficiency and remains the operation of choice for IMR. MVR, however, is preferred for select patients. Future randomized, prospective clinical trials are needed to directly compare these surgical techniques.
缺血性二尖瓣反流(IMR)是发病率和死亡率的主要来源。尽管二尖瓣修复术最近已广泛用于治疗 IMR,但某些患者可能从置换中受益。本文旨在描述 IMR 的当前手术选择,并讨论何时二尖瓣置换术(MVR)可能优于二尖瓣修复术。
IMR 的治疗目前有单纯手术血运重建、二尖瓣修复或 MVR 三种选择。尽管单纯手术血运重建可能对轻度至中度 IMR 患者有益,但大多数外科医生主张将血运重建与二尖瓣修复或置换相结合。在当前时代,与 MVR 相比,二尖瓣修复术已被证明可提供更好的短期和长期存活率、降低瓣膜相关发病率和改善左心室功能。然而,对于高危患者和 IMR 有特定潜在机制的患者,应考虑 MVR。
在缺乏一级证据的情况下,二尖瓣修复术为二尖瓣关闭不全的治疗提供了一种有效且持久的手术方法,仍然是 IMR 的首选手术。然而,对于某些患者,MVR 更为优选。需要未来的随机、前瞻性临床试验来直接比较这些手术技术。