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[左心室肥厚的各种形式:超声心动图的诊断价值]

[The various forms of left ventricular hypertrophy: diagnostic value of echocardiography].

作者信息

Weidemann F, Störk S, Herrmann S, Ertl G, Niemann M

机构信息

Medizinische Klinik und Poliklinik I, Herz- und Kreislaufzentrum, Universität Würzburg, Oberdürbacherstr. 6, 97080, Würzburg, Deutschland.

出版信息

Herz. 2011 Dec;36(8):713-23. doi: 10.1007/s00059-010-3416-1.

Abstract

Left ventricular hypertrophy is a non-specific physiological or maladaptive cardiac response to a large array of stimuli mediated by exercise and numerous cardiac and systemic diseases. The precise characterization and quantification of left ventricular hypertrophy may allow a more timely diagnosis of the underlying condition. The clinical reference standard to assess left ventricular hypertrophy is echocardiography, but a comprehensive description of how to approach this frequent finding in clinical practice is lacking. The current review systematically describes the typical echocardiographic patterns of important types of cardiac hypertrophy using both established and advanced imaging modalities. In hypertrophic obstructive cardiomyopathy a markedly reduced regional systolic function is found in the prominent thickened septum, whereas in essential arterial hypertension a typical concentric left ventricular hypertrophy with a less prominent basal septal bulge is present. The echocardiographic characteristics of cardiac amyloidosis are ventricular hypertrophy with sparkling granular myocardial texture and a small epicardial effusion. In addition, the strain rate curve for longitudinal function shows a typically reduced function which reaches maximum already in early systole. The typical feature of Friedreich cardiomyopathy is concentric left ventricular hypertrophy and sparkling granular texture with preserved regional systolic function. In Fabry cardiomyopathy a prominent papillary muscle is presented and a typical strain rate curve can be extracted from the basal lateral wall, indicating replacement fibrosis. Prominent hypertrabecularisation (ratio of non-compacted to compacted myocardium >2) in the apical and mid left ventricular segments is typical for non-compaction cardiomyopathy. Knowledge of these typical echocardiographic features enables the cardiologist to distinguish between the different hypertrophic entities, thus paving the way to early diagnosis.

摘要

左心室肥厚是一种非特异性的生理或适应性不良的心脏反应,由运动以及众多心脏和全身性疾病介导的一系列刺激引起。左心室肥厚的精确特征描述和量化可能有助于更及时地诊断潜在疾病。评估左心室肥厚的临床参考标准是超声心动图,但缺乏关于在临床实践中如何处理这一常见发现的全面描述。本综述系统地描述了使用既定和先进成像方式的重要类型心脏肥厚的典型超声心动图模式。在肥厚型梗阻性心肌病中,在明显增厚的室间隔中发现区域收缩功能明显降低,而在原发性高血压中,存在典型的同心性左心室肥厚,基底室间隔隆起不明显。心脏淀粉样变性的超声心动图特征是心室肥厚,心肌质地呈闪烁颗粒状,并有少量心包积液。此外,纵向功能的应变率曲线显示功能通常降低,在收缩早期即达到最大值。弗里德赖希心肌病的典型特征是同心性左心室肥厚和闪烁颗粒状质地,区域收缩功能保留。在法布里心肌病中,可见明显的乳头肌,并且可以从基底侧壁提取典型的应变率曲线,表明存在替代性纤维化。心尖和左心室中段明显的小梁化(非致密心肌与致密心肌的比率>2)是致密化不全心肌病的典型表现。了解这些典型的超声心动图特征使心脏病专家能够区分不同的肥厚性病变,从而为早期诊断铺平道路。

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