Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India.
J Surg Oncol. 2011 Mar 1;103(3):217-22. doi: 10.1002/jso.21768. Epub 2011 Jan 18.
Obesity is caused by disturbances of energy balance, which is homeostasized by the physiological processes. The study aims to determine the possible impact of rising prevalence of obesity and its effect in the development of breast carcinoma (BC) in Indian population.
This study is carried out on patients (N = 358) who were diagnosed with BC and breast diseases (BD) by calculating their BMI admitted during the period of 2005 to 2009. NIH criteria were used to categorize the patients. Pathological factors of BC patient were then compared among groups.
These results were indicative of significant positive association between BC risks with peri/post menopausal status, residence, diet nature, and tobacco uses. Metastases were identified more commonly with increasing weight. It was found to be independently associated with obesity I (OR = 3.103, 95% CI = 1.633-5.895) and obesity II (OR = 6.803, 95% CI = 2.415-19.162). Disease stage and cancer related mortality were significantly associated with increased BMI.
The higher prevalence of severe obesity among Indian population was associated with BC. The only alteration apart from early diagnosis is opting for a more natural lifestyle that will affect energy equilibrium and prove to be a viable option for prevention in carcinoma of breast for better survival.
肥胖是由能量平衡紊乱引起的，而能量平衡是由生理过程来维持的。本研究旨在确定肥胖症发病率的上升及其对印度人口中乳腺癌（BC）发展的可能影响。
本研究对 2005 年至 2009 年间通过计算 BMI 诊断为 BC 和乳腺疾病（BD）的 358 名患者进行了研究。使用 NIH 标准对患者进行分类。然后比较了 BC 患者的病理因素在各组之间的差异。
这些结果表明，BC 风险与绝经前后状态、居住地、饮食性质和烟草使用之间存在显著的正相关。随着体重的增加，转移更为常见。肥胖症 I（OR = 3.103，95%CI = 1.633-5.895）和肥胖症 II（OR = 6.803，95%CI = 2.415-19.162）与肥胖症独立相关。疾病分期和癌症相关死亡率与 BMI 的增加显著相关。
印度人口中严重肥胖症的更高患病率与 BC 相关。除了早期诊断之外，唯一的改变是选择更自然的生活方式，这将影响能量平衡，并为更好的生存提供预防乳腺癌的可行选择。
