5-溴脱氧尿苷对痘苗病毒和猴痘病毒的不同抑制作用。
Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses.
作者信息
Yoshii T, Kono R
出版信息
J Hyg (Lond). 1978 Oct;81(2):171-7. doi: 10.1017/s0022172400024992.
Abstract
Replication of vaccinia and monkeypox viruses was impeded in the presence of 5-bromodeoxyuridine (BUdR) in RL-33 cells derived from rabbit lung tissue. The different degree of inhibition was found among strains of those viruses, in which it was evident that five strains (CV-1, Lister, IHD, Dairen-I and Ikeda) of vaccinia viruses resulted in more reduced yields of infectious virus than four strains (Sen-19, Orang Utan, Copenhagen and Sierra Leone) of monkeypox viruses. There was also strain variation in BUdR sensitivity within vaccinia viruses but not in the case of monkeypox viruses.
摘要
在源自兔肺组织的RL-33细胞中，痘苗病毒和猴痘病毒的复制在5-溴脱氧尿苷（BUdR）存在的情况下受到阻碍。在这些病毒的毒株中发现了不同程度的抑制作用，其中明显的是，痘苗病毒的五个毒株（CV-1、李斯特、IHD、大连-I和池田）导致感染性病毒产量的降低程度高于猴痘病毒的四个毒株（森-19、猩猩、哥本哈根和塞拉利昂）。痘苗病毒内部在对BUdR的敏感性方面也存在毒株差异，但猴痘病毒不存在这种情况。
相似文献
1
Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses.5-溴脱氧尿苷对痘苗病毒和猴痘病毒的不同抑制作用。
J Hyg (Lond). 1978 Oct;81(2):171-7. doi: 10.1017/s0022172400024992.
2
Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses.骆驼痘病毒、牛痘病毒、猴痘病毒和痘苗病毒野生型及西多福韦耐药株的特性分析
Antimicrob Agents Chemother. 2002 May;46(5):1329-35. doi: 10.1128/AAC.46.5.1329-1335.2002.
3
[Effect of 5-bromouridine on the reproduction of vaccinia virus].
Biokhimiia. 1970 May-Jun;35(3):470-6.
4
Electron-microscopical observations on the development of vaccinia, cowpox and monkeypox viruses in pig skin.关于痘苗病毒、牛痘病毒和猴痘病毒在猪皮肤中生长发育的电子显微镜观察
Zentralbl Bakteriol Orig A. 1977 Apr;237(4):425-43.
5
Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus.猴痘病毒诱导合成的双链RNA比痘苗病毒少，并且比痘苗病毒更耐抗痘病毒药物IBT。
Virology. 2016 Oct;497:125-135. doi: 10.1016/j.virol.2016.07.016. Epub 2016 Jul 26.
6
Investigation of the mechanism of changes of RS character of neurovaccine in passages in the presence of bromodeoxyuridine.
J Gen Virol. 1970 Mar;6(3):355-9. doi: 10.1099/0022-1317-6-3-355.
7
Effect of some proteolytic enzymes on the plaque titer of vaccinia and rabbitpox viruses.
Virology. 1969 Aug;38(4):503-11. doi: 10.1016/0042-6822(69)90170-6.
8
Influence of progesterone on orthopox viruses in vitro and in vivo.
Zentralbl Veterinarmed B. 1987 Nov;34(9):684-90. doi: 10.1111/j.1439-0450.1987.tb00449.x.
9
Orthopoxvirus strains defective in surface antigen induction.在表面抗原诱导方面存在缺陷的正痘病毒株。
J Gen Virol. 1979 Jul;44(1):265-9. doi: 10.1099/0022-1317-44-1-265.
10
Nucleotide sequence comparison of homologous genomic regions from variola, monkeypox, and vaccinia viruses.天花病毒、猴痘病毒和痘苗病毒同源基因组区域的核苷酸序列比较。
J Med Virol. 1990 Aug;31(4):267-71. doi: 10.1002/jmv.1890310405.
引用本文的文献
1
Mpox Virus as a Global Public Health Emergency: A Scoping Review.猴痘病毒作为全球突发公共卫生事件：一项范围综述
Can J Infect Dis Med Microbiol. 2025 Jan 22;2025:6683501. doi: 10.1155/cjid/6683501. eCollection 2025.
2
Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs: A WEB prediction approach.猴痘病毒核心治疗靶点的鉴定及药物重新利用潜力：一种网络预测方法。
PLoS One. 2024 Dec 6;19(12):e0303501. doi: 10.1371/journal.pone.0303501. eCollection 2024.
本文引用的文献
1
THE EFFECT OF LIGHT ON POLIOVIRUS GROWN IN NEUTRAL RED.光照对在中性红中生长的脊髓灰质炎病毒的影响。
Virology. 1965 May;26:1-9. doi: 10.1016/0042-6822(65)90019-x.
2
Conditional lethal mutants of rabbitpox virus. I. Isolation of host cell-dependent and temperature-dependent mutants.
Virology. 1966 Apr;28(4):592-9. doi: 10.1016/0042-6822(66)90244-3.
3
Smallpox and monkeypox in non-human primates.非人灵长类动物中的天花和猴痘。
Bull World Health Organ. 1968;39(2):277-83.
4
Human infection with monkeypox virus: laboratory investigation of six cases in West Africa.人类感染猴痘病毒：西非6例病例的实验室调查
Bull World Health Organ. 1972;46(5):633-9.
5
An unusual poxvirus from Nigeria.一种来自尼日利亚的罕见痘病毒。
Bull World Health Organ. 1972;46(5):621-3.
6
Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man.人类新型天花样疾病（猴痘）病原体的分离与特性研究
Bull World Health Organ. 1972;46(5):599-611.
7
"White" poxvirus strains from monkeys.来自猴子的“白色”痘病毒毒株。
Bull World Health Organ. 1972;46(5):585-92.
8
Histopathological and virological studies on monkeypox.猴痘的组织病理学和病毒学研究。
Arch Gesamte Virusforsch. 1967;21(2):205-16. doi: 10.1007/BF01241445.
9
Three specific antigens produced in vaccinia, variola, and monkeypox infections.牛痘、天花和猴痘感染中产生的三种特定抗原。
J Infect Dis. 1974 Mar;129(3):289-95. doi: 10.1093/infdis/129.3.289.
10
Establishement of a rabbit lung cell line (RL-33) and its viral susceptibility.
Jpn J Med Sci Biol. 1977 Jun;30(3):149-57. doi: 10.7883/yoken1952.30.149.
Zotero 插件