Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador.
Clin Immunol. 2011 Mar;138(3):299-310. doi: 10.1016/j.clim.2010.12.011. Epub 2011 Jan 17.
The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5 years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6-9 months, 22-26 months, and 48-60 months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4(+) and CD8(+) T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3(+) T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.
儿童早期发育的免疫反应是引发哮喘等炎症性疾病的基础，而来自拉丁美洲热带地区（LA）的数据却很少。本研究通过比较厄瓜多尔 6-9 个月、22-26 个月和 48-60 个月大的儿童的固有和适应性免疫反应，研究了在生命的头 5 年中年龄对免疫发育的影响。幼稚 CD4+T 细胞的百分比随年龄的增长而下降，而记忆 CD4(+)和 CD8(+)T 细胞的百分比则增加，表明整个头 5 年免疫系统都在活跃发育。与年龄较大的儿童相比，年幼的婴儿对 TLR 激动剂有更强的固有免疫反应，而包括 SEB 诱导的 IL-10 和 FoxP3+T 调节细胞的百分比在内的调节反应则随年龄的增长而下降。生命早期增强的固有免疫可能对宿主防御病原体很重要，但也可能增加免疫病理学的风险。
