巴西艾滋病患者的等位基因与巨细胞病毒性视网膜炎
Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS.
作者信息
Biberg-Salum Tânia Gisela, Veronese Rodrigues Maria de Lourdes, Fernandes Ana Paula Morais, Deghaide Neifi Hassan Salum, de Paula Jayter Silva, Castelli Erick C, Mendes-Junior Celso Teixeira, Donadi Eduardo Antonio
机构信息
Ribeirao Preto Medical School, University of São Paulo, University for Development of Pantanal Region (UNIDERP), São Paulo, SP, Brazil.
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of São Paulo, São Paulo, SP, Brazil.
出版信息
J Ophthalmol. 2018 Sep 2;2018:3830104. doi: 10.1155/2018/3830104. eCollection 2018.
PURPOSE
Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and alleles have been associated with AIDS disease outcome, we typed locus in patients with AIDS exhibiting or not CR.
METHODS
Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). typing was performed using commercial kits.
RESULTS
The 07 allele group was underrepresented in AIDS patients with CR (=0.005) when compared to controls or when compared to AIDS patients without CR (=0.006). The 05 allele group was overrepresented in Group II in comparison to Group III (=0.017). The frequency of the 16 allele group was increased in Group III in comparison to Group II (=0.004).
CONCLUSION
The 07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the 05 and 16 allele groups were associated with AIDS susceptibility or protection, respectively.
目的
由于巨细胞病毒性视网膜炎（CR）是艾滋病患者视力损害的重要原因，且等位基因与艾滋病疾病转归相关，我们对患有或未患有CR的艾滋病患者的[具体基因座名称未给出]基因座进行了分型。
方法
研究了三组个体：（i）49例患有艾滋病且患有CR的患者（第一组），（ii）161例患有艾滋病但未患有CR的患者（第二组），以及（iii）202名健康的HIV阴性个体（第三组）。使用商业试剂盒进行[基因座名称未给出]分型。
结果
与对照组相比，或与未患有CR的艾滋病患者相比（P = 0.006），患有CR的艾滋病患者中07等位基因组的比例较低（P = 0.005）。与第三组相比，第二组中05等位基因组的比例过高（P = 0.017）。与第二组相比，第三组中16等位基因组的频率增加（P = 0.004）。
结论
07等位基因组对巴西艾滋病患者CR的发生具有保护作用，而05和16等位基因组分别与艾滋病易感性或保护作用相关。
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