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铜催化的 N-烯基脒的有氧[3+2]-环加成反应。

Copper-catalyzed aerobic [3+2]-annulation of N-alkenyl amidines.

机构信息

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

出版信息

J Am Chem Soc. 2012 Feb 29;134(8):3679-82. doi: 10.1021/ja2120629. Epub 2012 Feb 10.

DOI:10.1021/ja2120629
PMID:22296256
Abstract

A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

摘要

一种双环和三环脒的合成方法已经通过铜催化的 N-烯基脒的有氧[3+2]-环化反应发展起来。这些环状脒可以通过氢化铝还原转化为单苄基保护的邻二胺。

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