Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA.
J Org Chem. 2011 Mar 4;76(5):1390-7. doi: 10.1021/jo102385u. Epub 2011 Jan 21.
The use of commercially available (SIPr)Pd(cinnamyl)Cl (SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene) as a precatalyst for the anaerobic oxidation of secondary alcohols is described. The use of this complex allows for a drastic reduction in the reaction times and catalyst loading when compared to the unsaturated counterpart. This catalytic system is compatible with the use of microwave dielectric heating, decreasing even further catalyst loading and reaction times. Domino Pd-catalyzed oxidation-arylation reactions of secondary alcohols are also presented.
本文描述了商业可得的（SIPr）Pd（肉桂基）Cl（SIPr = 1,3-双（2,6-二异丙基苯基）-4,5-二氢咪唑-2-亚基）作为仲醇厌氧氧化的预催化剂的用途。与不饱和对应物相比，该配合物的使用可以大大缩短反应时间和催化剂用量。该催化体系与微波介电热兼容，甚至进一步降低了催化剂用量和反应时间。本文还介绍了仲醇的钯催化氧化-芳基化的多米诺反应。
