肿瘤相关巨噬细胞的极化：血管正常化和抗肿瘤免疫的新策略。
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
机构信息
Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.
Abstract
Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.
摘要
血管正常化是癌症治疗中的一个新兴概念。在本期《癌细胞》杂志中，Rolny 等人表明组氨酸丰富糖蛋白通过极化肿瘤相关巨噬细胞使肿瘤血管正常化，并促进抗肿瘤免疫，从而导致肿瘤生长和转移减少。巨噬细胞中胎盘生长因子的缺失可模拟许多这些作用。
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本文引用的文献
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HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.HRG 通过下调 PlGF 诱导巨噬细胞极化和血管正常化来抑制肿瘤生长和转移。
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Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.通过阻断VEGFR2实现血管正常化的动力学决定脑肿瘤对放疗的反应：氧合作用、血管生成素-1和基质金属蛋白酶的作用
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