肿瘤相关巨噬细胞的极化：血管正常化和抗肿瘤免疫的新策略。
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
机构信息
Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.
Abstract
Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.
摘要
血管正常化是癌症治疗中的一个新兴概念。在本期《癌细胞》杂志中，Rolny 等人表明组氨酸丰富糖蛋白通过极化肿瘤相关巨噬细胞使肿瘤血管正常化，并促进抗肿瘤免疫，从而导致肿瘤生长和转移减少。巨噬细胞中胎盘生长因子的缺失可模拟许多这些作用。
相似文献
1
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.
2
Polarization of tumor-associated macrophage is associated with tumor vascular normalization by endostatin.
Thorac Cancer. 2013 Aug;4(3):295-305. doi: 10.1111/1759-7714.12018.
3
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Cancer Cell. 2011 Jan 18;19(1):31-44. doi: 10.1016/j.ccr.2010.11.009. Epub 2011 Jan 6.
4
Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response.
J Immunother Cancer. 2023 Aug;11(8). doi: 10.1136/jitc-2023-007253.
5
Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma.
Toxicol Appl Pharmacol. 2015 Jul 15;286(2):112-23. doi: 10.1016/j.taap.2015.03.021. Epub 2015 Mar 25.
6
Leukocyte Differentiation by Histidine-Rich Glycoprotein/Stanniocalcin-2 Complex Regulates Murine Glioma Growth through Modulation of Antitumor Immunity.
Mol Cancer Ther. 2018 Sep;17(9):1961-1972. doi: 10.1158/1535-7163.MCT-18-0097. Epub 2018 Jun 26.
7
The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma.
Adv Sci (Weinh). 2023 Jun;10(18):e2207650. doi: 10.1002/advs.202207650. Epub 2023 Apr 21.
8
Dual role of endothelial in tumor angiogenesis and tumor immunity.
Sci Transl Med. 2021 Mar 3;13(583). doi: 10.1126/scitranslmed.abb6731.
9
UTMD inhibits pancreatic cancer growth and metastasis by inducing macrophage polarization and vessel normalization.
Biomed Pharmacother. 2023 Apr;160:114322. doi: 10.1016/j.biopha.2023.114322. Epub 2023 Feb 3.
10
PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy.
J Immunother Cancer. 2025 Apr 5;13(4):e011299. doi: 10.1136/jitc-2024-011299.
引用本文的文献
1
Exploring the mechanism of fibronectin extra domain B in the tumor microenvironment and implications for targeted immunotherapy and diagnostics (Review).
Mol Med Rep. 2025 Jun;31(6). doi: 10.3892/mmr.2025.13525. Epub 2025 Apr 11.
2
Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation.
Cancer Discov. 2025 Jul 3;15(7):1410-1436. doi: 10.1158/2159-8290.CD-24-0415.
3
Strategies for overcoming tumour resistance to immunotherapy: harnessing the power of radiation therapy.
Br J Radiol. 2024 Aug 1;97(1160):1378-1390. doi: 10.1093/bjr/tqae100.
4
Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy.
Asian J Pharm Sci. 2024 Apr;19(2):100902. doi: 10.1016/j.ajps.2024.100902. Epub 2024 Mar 11.
5
Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches.
J Exp Clin Cancer Res. 2023 Jul 22;42(1):177. doi: 10.1186/s13046-023-02729-7.
6
Novel Human Meningioma Organoids Recapitulate the Aggressiveness of the Initiating Cell Subpopulations Identified by ScRNA-Seq.
Adv Sci (Weinh). 2023 May;10(15):e2205525. doi: 10.1002/advs.202205525. Epub 2023 Mar 30.
7
Application of individualized multimodal radiotherapy combined with immunotherapy in metastatic tumors.
Front Immunol. 2023 Jan 12;13:1106644. doi: 10.3389/fimmu.2022.1106644. eCollection 2022.
8
Drug delivery strategy in hepatocellular carcinoma therapy.
Cell Commun Signal. 2022 Mar 5;20(1):26. doi: 10.1186/s12964-021-00796-x.
9
VEGF-Trap Modulates Retinal Inflammation in the Murine Oxygen-Induced Retinopathy (OIR) Model.
Biomedicines. 2022 Jan 18;10(2):201. doi: 10.3390/biomedicines10020201.
10
The Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy.
Front Oncol. 2021 Jun 29;11:641428. doi: 10.3389/fonc.2021.641428. eCollection 2021.
本文引用的文献
1
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Cancer Cell. 2011 Jan 18;19(1):31-44. doi: 10.1016/j.ccr.2010.11.009. Epub 2011 Jan 6.
2
Macrophages, innate immunity and cancer: balance, tolerance, and diversity.
Curr Opin Immunol. 2010 Apr;22(2):231-7. doi: 10.1016/j.coi.2010.01.009. Epub 2010 Feb 9.
3
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Cancer Cell. 2010 Feb 17;17(2):121-34. doi: 10.1016/j.ccr.2009.12.019. Epub 2010 Feb 4.
4
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12.
5
Vascular normalization in Rgs5-deficient tumours promotes immune destruction.
Nature. 2008 May 15;453(7193):410-4. doi: 10.1038/nature06868. Epub 2008 Apr 16.
6
Histidine-rich glycoprotein modulation of immune/autoimmune, vascular, and coagulation systems.
Clin Rev Allergy Immunol. 2008 Jun;34(3):307-12. doi: 10.1007/s12016-007-8058-6.
7
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Cell. 2007 Nov 2;131(3):463-75. doi: 10.1016/j.cell.2007.08.038.
8
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science. 2005 Jan 7;307(5706):58-62. doi: 10.1126/science.1104819.
9
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004 Dec;6(6):553-63. doi: 10.1016/j.ccr.2004.10.011.
10
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
Nat Med. 2001 Sep;7(9):987-9. doi: 10.1038/nm0901-987.
Zotero 插件