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肿瘤相关巨噬细胞的极化：血管正常化和抗肿瘤免疫的新策略。

Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.

机构信息

Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.

DOI:10.1016/j.ccr.2011.01.005
PMID:21251607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3037265/
Abstract

Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.

摘要

血管正常化是癌症治疗中的一个新兴概念。在本期《癌细胞》杂志中，Rolny 等人表明组氨酸丰富糖蛋白通过极化肿瘤相关巨噬细胞使肿瘤血管正常化，并促进抗肿瘤免疫，从而导致肿瘤生长和转移减少。巨噬细胞中胎盘生长因子的缺失可模拟许多这些作用。

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本文引用的文献

1
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.HRG 通过下调 PlGF 诱导巨噬细胞极化和血管正常化来抑制肿瘤生长和转移。
Cancer Cell. 2011 Jan 18;19(1):31-44. doi: 10.1016/j.ccr.2010.11.009. Epub 2011 Jan 6.
2
Macrophages, innate immunity and cancer: balance, tolerance, and diversity.巨噬细胞、先天免疫与癌症：平衡、耐受与多样性。
Curr Opin Immunol. 2010 Apr;22(2):231-7. doi: 10.1016/j.coi.2010.01.009. Epub 2010 Feb 9.
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FcRgamma activation regulates inflammation-associated squamous carcinogenesis.FcRγ 激活调控炎症相关鳞状细胞癌发生。
Cancer Cell. 2010 Feb 17;17(2):121-34. doi: 10.1016/j.ccr.2009.12.019. Epub 2010 Feb 4.
4
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.PHD2杂合性缺陷通过内皮细胞正常化恢复肿瘤氧合并抑制转移。
Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12.
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Vascular normalization in Rgs5-deficient tumours promotes immune destruction.Rgs5基因缺陷型肿瘤中的血管正常化促进免疫破坏。
Nature. 2008 May 15;453(7193):410-4. doi: 10.1038/nature06868. Epub 2008 Apr 16.
6
Histidine-rich glycoprotein modulation of immune/autoimmune, vascular, and coagulation systems.富含组氨酸糖蛋白对免疫/自身免疫、血管和凝血系统的调节作用。
Clin Rev Allergy Immunol. 2008 Jun;34(3):307-12. doi: 10.1007/s12016-007-8058-6.
7
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.抗胎盘生长因子可抑制对血管内皮生长因子受体（VEGF(R)）抑制剂耐药的肿瘤生长，且不影响健康血管。
Cell. 2007 Nov 2;131(3):463-75. doi: 10.1016/j.cell.2007.08.038.
8
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.肿瘤血管正常化：抗血管生成治疗中的一个新兴概念。
Science. 2005 Jan 7;307(5706):58-62. doi: 10.1126/science.1104819.
9
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.通过阻断VEGFR2实现血管正常化的动力学决定脑肿瘤对放疗的反应：氧合作用、血管生成素-1和基质金属蛋白酶的作用
Cancer Cell. 2004 Dec;6(6):553-63. doi: 10.1016/j.ccr.2004.10.011.
10
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.用抗血管生成疗法使肿瘤血管正常化：联合治疗的新范例。
Nat Med. 2001 Sep;7(9):987-9. doi: 10.1038/nm0901-987.