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1
Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.铜绿假单胞菌染色体 AmpC β-内酰胺酶结构基因及调控区的克隆、测序与分析
Biochem J. 1990 Dec 15;272(3):627-31. doi: 10.1042/bj2720627.
2
Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter.铜绿假单胞菌ampR基因及其在染色体ampCβ-内酰胺酶启动子处作用的研究。
FEMS Microbiol Lett. 1993 Aug 1;111(2-3):315-20. doi: 10.1111/j.1574-6968.1993.tb06404.x.
3
Characterization of a plasmid-borne and constitutively expressed blaMOX-1 gene encoding AmpC-type beta-lactamase.编码AmpC型β-内酰胺酶的质粒携带型组成型表达blaMOX-1基因的特性分析
Gene. 1994 Feb 11;139(1):93-8. doi: 10.1016/0378-1119(94)90529-0.
4
Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases.铜绿假单胞菌PER-1超广谱β-内酰胺酶的序列分析及其与A类β-内酰胺酶的比较。
Antimicrob Agents Chemother. 1994 Jan;38(1):104-14. doi: 10.1128/AAC.38.1.104.
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Purification and mutant analysis of Citrobacter freundii AmpR, the regulator for chromosomal AmpC beta-lactamase.弗氏柠檬酸杆菌AmpR（染色体AmpCβ-内酰胺酶的调节因子）的纯化及突变分析
Mol Microbiol. 1991 Jul;5(7):1715-25. doi: 10.1111/j.1365-2958.1991.tb01920.x.
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Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.从囊性纤维化患者中分离出的铜绿假单胞菌菌株具有不同的β-内酰胺酶表达表型，但在ampC-ampR基因区域是同源的。
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Common mechanism of ampC beta-lactamase induction in enterobacteria: regulation of the cloned Enterobacter cloacae P99 beta-lactamase gene.肠杆菌中AmpCβ-内酰胺酶诱导的常见机制：阴沟肠杆菌P99β-内酰胺酶基因克隆的调控
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Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis.香港拉氏菌中一种染色体C类β-内酰胺酶及其调控基因的克隆与特性分析
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Inducible expression of the chromosomal cdiA from Citrobacter diversus NF85, encoding an ambler class A beta-lactamase, is under similar genetic control to the chromosomal ampC, encoding an ambler class C enzyme, from Citrobacter freundii OS60.来自奇异柠檬酸杆菌NF85的编码安布勒A类β-内酰胺酶的染色体cdiA的可诱导表达，与来自弗氏柠檬酸杆菌OS60的编码安布勒C类酶的染色体ampC受相似的遗传控制。
Microb Drug Resist. 1995 Winter;1(4):285-91. doi: 10.1089/mdr.1995.1.285.

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Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex.头孢唑林和亚胺培南以依赖于 NagZ 的方式增强阴沟肠杆菌复合体中的 AmpC 表达和耐药性。
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Alternatives to Conventional Antibiotic Therapy: Potential Therapeutic Strategies of Combating Antimicrobial-Resistance and Biofilm-Related Infections.替代传统抗生素治疗：对抗抗微生物耐药性和生物膜相关感染的潜在治疗策略。
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10
Elevating NagZ Improves Resistance to β-Lactam Antibiotics via Promoting AmpC β-Lactamase in .提高NagZ通过促进AmpCβ-内酰胺酶增强对β-内酰胺类抗生素的抗性 。（注：原文句子似乎不完整，“in”后面缺少具体内容）
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本文引用的文献

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Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.通过在大肠杆菌中进行DNA融合和克隆分析基因控制信号。
J Mol Biol. 1980 Apr;138(2):179-207. doi: 10.1016/0022-2836(80)90283-1.
2
Active sites of beta-lactamases. The chromosomal beta-lactamases of Pseudomonas aeruginosa and Escherichia coli.β-内酰胺酶的活性位点。铜绿假单胞菌和大肠杆菌的染色体β-内酰胺酶。
Biochem J. 1982 Mar 1;201(3):621-7. doi: 10.1042/bj2010621.
3
ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.大肠杆菌K-12的AmpC头孢菌素酶与青霉素酶型β-内酰胺酶有着不同的进化起源。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4897-901. doi: 10.1073/pnas.78.8.4897.
4
Development of resistance to cephalosporins in clinical strains of Citrobacter spp.柠檬酸杆菌临床菌株对头孢菌素耐药性的产生
Antimicrob Agents Chemother. 1984 May;25(5):591-5. doi: 10.1128/AAC.25.5.591.
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A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
6
Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins.阴沟肠杆菌的染色体β-内酰胺酶是导致对第三代头孢菌素耐药的原因。
Antimicrob Agents Chemother. 1983 Jun;23(6):918-25. doi: 10.1128/AAC.23.6.918.
7
Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants.一种广宿主范围黏粒克隆载体的构建及其在根瘤菌突变体遗传分析中的应用。
Gene. 1982 Jun;18(3):289-96. doi: 10.1016/0378-1119(82)90167-6.
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Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.利用单链噬菌体克隆辅助快速DNA测序。
J Mol Biol. 1980 Oct 25;143(2):161-78. doi: 10.1016/0022-2836(80)90196-5.
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Cephalosporinase and penicillinase activities of a beta-lactamase from Pseudomonas pyocyanea.铜绿假单胞菌β-内酰胺酶的头孢菌素酶和青霉素酶活性
Biochem J. 1965 Sep;96(3):739-52. doi: 10.1042/bj0960739.
10
Newer mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria.革兰氏阴性菌对β-内酰胺类抗生素耐药的新机制。
J Antimicrob Chemother. 1985 Sep;16(3):279-84. doi: 10.1093/jac/16.3.279.

铜绿假单胞菌染色体 AmpC β-内酰胺酶结构基因及调控区的克隆、测序与分析

Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.

作者信息

Lodge J M, Minchin S D, Piddock L J, Busby S J

机构信息

School of Biochemistry, University of Birmingham, U.K.

出版信息

Biochem J. 1990 Dec 15;272(3):627-31. doi: 10.1042/bj2720627.

DOI:10.1042/bj2720627
PMID:2125210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1149754/
Abstract

The chromosomal gene from Pseudomonas aeruginosa encoding beta-lactamase has been cloned, and the sequence determined and compared with corresponding sequences of beta-lactamases from members of the enterobacteriaceae. Upstream of the beta-lactamase gene is an open reading frame which we postulate encodes a regulatory protein, AmpR. We identified a helix-turn-helix region in AmpR and a putative AmpR-binding site.

摘要

编码β-内酰胺酶的铜绿假单胞菌染色体基因已被克隆，其序列已被测定，并与肠杆菌科成员的β-内酰胺酶相应序列进行了比较。β-内酰胺酶基因上游是一个开放阅读框，我们推测它编码一种调节蛋白AmpR。我们在AmpR中鉴定出一个螺旋-转角-螺旋区域和一个假定的AmpR结合位点。