Center of Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003 Barcelona, Spain.
Nat Rev Mol Cell Biol. 2011 Feb;12(2):79-89. doi: 10.1038/nrm3043.
The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.
再生医学的最终目标是替换丢失或损坏的细胞。这可以通过去分化、转分化或重编程等过程来实现。最近的进展表明，添加一组基因不仅可以恢复完全分化的细胞状态的多能性（重编程），还可以诱导细胞增殖（去分化）甚至转分化为另一种细胞类型。目前的研究旨在了解这些过程是如何工作的，并最终将其用于再生医学。
