Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Nat Rev Mol Cell Biol. 2011 Feb;12(2):104-17. doi: 10.1038/nrm3048.
Human-made information relay systems invariably incorporate central regulatory components, which are mirrored in biological systems by dense feedback and feedforward loops. This type of system control is exemplified by positive and negative feedback loops (for example, receptor endocytosis and dephosphorylation) that enable growth factors and receptor Tyr kinases of the epidermal growth factor receptor (EGFR)/ERBB family to regulate cellular function. Recent studies show that the collection of feedback regulatory loops can perform computational tasks - such as decoding ligand specificity, transforming graded input signals into a digital output and regulating response kinetics. Aberrant signal processing and feedback regulation can lead to defects associated with pathologies such as cancer.
人造信息传递系统无一例外地包含中央调节组件，而在生物系统中，这些组件则由密集的反馈和前馈回路来体现。这种系统控制的范例包括正反馈和负反馈回路（例如，受体胞吞作用和去磷酸化），它们使生长因子和表皮生长因子受体（EGFR）/ ERBB 家族的受体 Tyr 激酶能够调节细胞功能。最近的研究表明，反馈调节回路的集合可以执行计算任务 - 例如解码配体特异性，将分级输入信号转换为数字输出，并调节响应动力学。异常的信号处理和反馈调节可能导致与癌症等疾病相关的缺陷。
