Oda Kanae, Matsuoka Yukiko, Funahashi Akira, Kitano Hiroaki
The Systems Biology Institute, Tokyo, Japan.
Mol Syst Biol. 2005;1:2005.0010. doi: 10.1038/msb4100014. Epub 2005 May 25.
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well-defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).
表皮生长因子受体（EGFR）信号通路是调节哺乳动物细胞生长、存活、增殖和分化的最重要通路之一。这一重要性体现在，它是实验和计算方面研究得最为透彻的信号系统之一，并且已经开发了多个计算模型用于动态分析。EGFR信号系统的分子相互作用图谱是该领域研究的宝贵资源。在本文中，我们展示了EGFR信号通路及其他相关通路的综合通路图谱。该图谱显示，该通路的整体架构是具有多个反馈环的领结（或沙漏）结构。该图谱是使用CellDesigner软件创建的，该软件使我们能够使用定义明确且一致的图形符号以图形方式表示相互作用，并将其存储在系统生物学标记语言（SBML）中。
