Ishiwata I, Ishiwata C, Soma M, Naik D R, Hashimoto H, Sudo T, Ishikawa H
Ishiwata Obstetrics and Gynecology Hospital, Ibaraki, Japan.
Virchows Arch A Pathol Anat Histopathol. 1990;417(6):473-6. doi: 10.1007/BF01625726.
The effect of a tumour angiogenesis factor on proliferation of various kinds of cells was examined in vitro. The factor (TAF) a polypeptide of 14000 molecular weight, was extracted and purified from the conditioned medium of ovarian clear cell carcinoma cell line (HUOCA-II). TAF at concentrations of 10 ng/ml and 100 ng/ml promoted proliferation of the endothelial cells and induced tube formation. However, it had no stimulatory effect on the proliferation of fibroblasts, endometrial columnar cells, squamous epithelial cells or cancer cells.
在体外研究了肿瘤血管生成因子对各种细胞增殖的影响。该因子（TAF）是一种分子量为14000的多肽，从卵巢透明细胞癌细胞系（HUOCA-II）的条件培养基中提取并纯化。浓度为10 ng/ml和100 ng/ml的TAF促进内皮细胞增殖并诱导管形成。然而，它对成纤维细胞、子宫内膜柱状细胞、鳞状上皮细胞或癌细胞的增殖没有刺激作用。
