系统性红斑狼疮中的狼疮抗凝物：患病率及临床关联
Lupus anticoagulants in systemic lupus erythematosus: prevalence and clinical associations.
作者信息
Padmakumar K, Singh R R, Rai R, Malaviya A N, Saraya A K
机构信息
Department of Medicine, All-India Institute of Medical Sciences, New Delhi.
出版信息
Ann Rheum Dis. 1990 Dec;49(12):986-9. doi: 10.1136/ard.49.12.986.
The prevalence of lupus anticoagulant (LAC) and its relation with reported clinical associations has been determined in 55 patients with systemic lupus erythematosus (SLE) from northern India who were studied prospectively. Kaolin clotting time was used to screen for LAC, which was detected in seven (13%) of the patients. Significant associations were found between LAC and thrombotic events, onset of disease at an early age, and disease of shorter duration. No statistically significant association could be found between LAC and recurrent abortions, pulmonary hypertension, thrombocytopenia, and neurological manifestations. It is concluded that LAC is a useful marker for a subset of patients with SLE at risk of thromboembolic events.
对来自印度北部的55例系统性红斑狼疮（SLE）患者进行了前瞻性研究，以确定狼疮抗凝物（LAC）的患病率及其与所报告临床关联的关系。采用高岭土凝血时间筛查LAC，7例（13%）患者检测到LAC。发现LAC与血栓形成事件、发病年龄早和病程短之间存在显著关联。未发现LAC与反复流产、肺动脉高压、血小板减少症和神经表现之间存在统计学上的显著关联。结论是，LAC是SLE患者中发生血栓栓塞事件风险的一个有用标志物。
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