系统性红斑狼疮中的血栓形成：与循环狼疮抗凝物的存在显著相关。
Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant.
作者信息
Boey M L, Colaco C B, Gharavi A E, Elkon K B, Loizou S, Hughes G R
出版信息
Br Med J (Clin Res Ed). 1983 Oct 8;287(6398):1021-3. doi: 10.1136/bmj.287.6398.1021.
Abstract
The lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders (mixed connective tissue disease, systemic vasculitis, polyarteritis nodosa, primary sicca syndrome, discoid lupus, Behcet's syndrome, and systemic sclerosis). Strong associations were found with biological false positive seroreaction for syphilis and thrombocytopenia. The most striking association, however, was with the high prevalence of thrombosis. This tendency to thrombosis was independent of disease activity of systemic lupus erythematosus. The lupus anticoagulant appears to be a useful marker for a subset of patients with systemic lupus erythematosus at risk for the development of thromboembolic complications.
摘要
在60例系统性红斑狼疮及其他结缔组织疾病（混合性结缔组织病、系统性血管炎、结节性多动脉炎、原发性干燥综合征、盘状红斑狼疮、白塞综合征和系统性硬化症）患者中，有31例患者的血浆中发现了狼疮抗凝物。研究发现，狼疮抗凝物与梅毒生物学假阳性血清反应和血小板减少症密切相关。然而，最显著的关联是与血栓形成的高发生率有关。这种血栓形成倾向与系统性红斑狼疮的疾病活动无关。狼疮抗凝物似乎是系统性红斑狼疮患者中一部分有发生血栓栓塞并发症风险的患者的有用标志物。
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