Völkl-Kernstock S, Willinger U, Feucht M
Department of Neuropsychiatry for Children and Adolescents, A-1090 Vienna, Währinger Gürtel 18-20, Austria.
Epilepsy Res. 2006 Nov;72(1):39-48. doi: 10.1016/j.eplepsyres.2006.07.004. Epub 2006 Aug 30.
Despite the benign prognosis regarding the response of seizures to treatment, some evidence now exists that patients with benign childhood epilepsy with centro-temporal spikes (BCECTS) may have neuropsychological deficits sometimes leading to academic underachievement. There is, however, no general agreement on the exact profile of functions disturbed. This study was designed to identify significant deficits in spatial perception and memory in children with BCECTS (ages 6-10 years) compared with healthy controls matched for age, sex and socioeconomic status. The neuropsychological test battery administered consisted of the HAWIK-III, the "Tübinger Luria Christensen Neuropsychological Test Set for Children", the "Kaufman Assessment Battery for Children" and the "Differential Neuropsychological Test". Twenty-two patients and 22 control subjects completed all tests. Children with BCECTS exhibited significant deficits in higher functions of spatial perception, including spatial orientation, as well as in basal and complex spatial memory. Deficits were independent of the lateralization of the epileptogenic foci and independent of anti-convulsive drug treatment.
尽管癫痫发作对治疗的反应预后良好，但现在有一些证据表明，患有中央颞区棘波的儿童良性癫痫（BCECTS）患者可能存在神经心理缺陷，有时会导致学业成绩不佳。然而，对于受干扰功能的确切概况并没有普遍共识。本研究旨在确定与年龄、性别和社会经济地位相匹配的健康对照组相比，BCECTS儿童（6至10岁）在空间感知和记忆方面的显著缺陷。所使用的神经心理测试组合包括HAWIK-III、“图宾根儿童卢里亚·克里斯滕森神经心理测试集”、“考夫曼儿童评估量表”和“差异神经心理测试”。22名患者和22名对照受试者完成了所有测试。BCECTS儿童在空间感知的高级功能（包括空间定向）以及基础和复杂空间记忆方面表现出显著缺陷。这些缺陷与致痫灶的定位无关，也与抗惊厥药物治疗无关。
