Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Center for Psychosocial Research, 676N. St. Clair, Suite 1400, Chicago, IL 60611, USA.
Behav Res Ther. 2011 Mar;49(3):145-50. doi: 10.1016/j.brat.2010.12.005. Epub 2010 Dec 30.
Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse.
We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following behavioral intervention when compared to the natural history of flare incidence prior to program participation.
Results from a 2-level regression model indicated that those participants in the treatment group were 57% less likely to flare in the following 12 months (compared to 18% in the control group). The decline in "flare odds" was about 2 times greater in treatment versus controls (OR=0.52, t(34)=2.07, p<0.05). Office visits, ER visits, and disease severity (all p<0.05) were identified as moderators of flare risk.
We have demonstrated 1) a statistical model estimating the likelihood of flare rates in the 12 months following a behavioral intervention for IBD (compared to a control condition), and 2) that the introduction of a behavioral intervention can alter the natural course of a chronic, relapsing and remitting gastrointestinal condition such as IBD.
我们旨在确定与行为干预前疾病复发的自然病程相比，在行为干预后 12 个月内参与行为自我管理计划对炎症性肠病（IBD）患者发病的影响。
2 水平回归模型的结果表明，治疗组患者在随后的 12 个月内复发的可能性降低了 57%（而对照组为 18%）。与对照组相比，治疗组的“复发几率”下降了约 2 倍（OR=0.52，t（34）=2.07，p<0.05）。就诊次数、急诊就诊次数和疾病严重程度（均 p<0.05）被确定为疾病复发风险的调节剂。
我们已经证明了 1）在 IBD 患者进行行为干预后的 12 个月内（与对照组相比），预测疾病复发率的统计模型，以及 2）引入行为干预可以改变 IBD 等慢性、复发性和缓解性胃肠道疾病的自然病程。
