Department of Orthopedics Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
J Arthroplasty. 2011 Dec;26(8):1534-9. doi: 10.1016/j.arth.2010.10.008. Epub 2011 Jan 21.
Simvastatin was recently demonstrated to stimulate bone morphogenetic protein-2 expression, leading to bone formation. The present study was designed to evaluate whether simvastatin administered by injection could promote osseointegration in a canine total hip arthroplasty model. Fifteen dogs were divided into 3 groups of 5 dogs each: group 1 (high-dosage simvastatin, 6.0 mg/[kg d]), group 2 (low-dosage simvastatin, 3.0 mg/[kg d]), and a control group (isotonic saline, 3.0 mg/[kg d]). Osseointegration was assessed by using the push-out test, scanning electron microscopy, energy-dispersive spectrometer microanalysis, and histomorphometric examination. The results showed higher mechanical strength, greater area of bone covering the femoral component, and higher bone-implant contact in group 1 than in the other 2 groups. Our findings indicate that simvastatin administered by injection could contribute significantly to osseointegration in a canine total hip arthroplasty model.
辛伐他汀最近被证明可刺激骨形态发生蛋白-2 的表达，从而促进骨形成。本研究旨在评估注射用辛伐他汀是否可促进犬全髋关节置换模型中的骨整合。15 只狗分为 3 组，每组 5 只：第 1 组（高剂量辛伐他汀，6.0mg/[kg d]），第 2 组（低剂量辛伐他汀，3.0mg/[kg d]）和对照组（等渗盐水，3.0mg/[kg d]）。通过推出试验、扫描电子显微镜、能谱微分析和组织形态计量学检查评估骨整合。结果表明，第 1 组的机械强度更高，股骨部件覆盖的骨面积更大，骨-植入物接触率更高。我们的研究结果表明，注射用辛伐他汀可显著促进犬全髋关节置换模型中的骨整合。
