用于改善骨生成的表面改性钛及钛基合金：综述

Surface-modified titanium and titanium-based alloys for improved osteogenesis: A critical review.

作者信息

Li Jingling, Zheng Yaxin, Yu Zihe, Kankala Ranjith Kumar, Lin Qianying, Shi Jingbo, Chen Chao, Luo Kai, Chen Aizheng, Zhong Quan

机构信息

Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Institute of Stomatology & Laboratory of Oral Tissue Engineering, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

出版信息

Heliyon. 2023 Dec 18;10(1):e23779. doi: 10.1016/j.heliyon.2023.e23779. eCollection 2024 Jan 15.

DOI:10.1016/j.heliyon.2023.e23779

PMID:38223705

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10784177/

Abstract

As implantable materials, titanium, and its alloys have garnered enormous interest from researchers for dental and orthopedic procedures. Despite their success in wide clinical applications, titanium, and its alloys fail to stimulate osteogenesis, resulting in poor bonding strength with surrounding bone tissue. Optimizing the surface topology and altered compositions of titanium and titanium-based alloys substantially promotes peri-implant bone regeneration. This review summarizes the utilization and importance of various osteogenesis components loaded onto titanium and its alloys. Further, different surface-modification methods and the release efficacy of loaded substances are emphasized. Finally, we summarize the article with prospects. We believe that further investigation studies must focus on identifying novel loading components, exploring various innovative, optimized surface-modification methods, and developing a sustained-release system on implant surfaces to improve peri-implant bone formation.

摘要

作为可植入材料，钛及其合金在牙科和骨科手术中引起了研究人员的极大兴趣。尽管它们在广泛的临床应用中取得了成功，但钛及其合金无法刺激骨生成，导致与周围骨组织的结合强度较差。优化钛及钛基合金的表面拓扑结构和改变其成分可显著促进种植体周围骨再生。本综述总结了负载在钛及其合金上的各种成骨成分的应用和重要性。此外，还强调了不同的表面改性方法和负载物质的释放效果。最后，我们对本文进行了展望总结。我们认为，进一步的研究必须集中在识别新型负载成分、探索各种创新的、优化的表面改性方法以及开发植入体表面的缓释系统，以改善种植体周围骨形成。