Başarir Kerem, Erdemli Bülent, Can Alp, Erdemli Esra, Zeyrek Tuğba
Department of Orthopaedic Surgery, Ankara University School of Medicine, Ankara, Turkey.
Int Orthop. 2009 Jun;33(3):855-9. doi: 10.1007/s00264-007-0490-y. Epub 2007 Dec 21.
Cementless fixation depends on bone ingrowth for long-term success. Simvastatin as a lipid lowering agent has been demonstrated to have osteoanabolic effects. This study was designed to measure the possible effect of simvastatin on implant osseointegration. Bilateral femoral implantation of titanium cylinders was performed in 20 rabbits. Blood lipid levels were measured pre- and postoperatively. Scanning electron microscopy (SEM) was used to measure the percentage of the surface of each implant in contact with bone and mechanical pull-out testing was performed. The blood lipid levels were significantly reduced in the simvastatin group. Histomorphometric examination revealed increased bone ingrowth and mechanical examination showed increased interface strength in the simvastatin group. Mechanical and histological data showed superior stability and osseous adaptation at the bone/implant interface for the simvastatin group. We conclude that simvastatin has potential as a means of enhancing bone ingrowth, which is a key factor in the longevity of cementless implants.
非骨水泥固定的长期成功依赖于骨长入。辛伐他汀作为一种降脂药物已被证明具有骨合成代谢作用。本研究旨在测量辛伐他汀对种植体骨整合的可能影响。对20只兔子进行双侧股骨钛柱植入。在术前和术后测量血脂水平。使用扫描电子显微镜（SEM）测量每个植入体与骨接触的表面百分比，并进行机械拔出试验。辛伐他汀组的血脂水平显著降低。组织形态计量学检查显示辛伐他汀组骨长入增加，机械检查显示界面强度增加。机械和组织学数据表明，辛伐他汀组在骨/植入体界面处具有更好的稳定性和骨适应性。我们得出结论，辛伐他汀有潜力作为增强骨长入的一种手段，而骨长入是非骨水泥植入物长期使用的关键因素。
