Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Int J Pharm. 2011 Sep 30;417(1-2):101-11. doi: 10.1016/j.ijpharm.2011.01.022. Epub 2011 Jan 21.
The use of X-ray scattering techniques in pharmaceutical science is increasing, in part through increased collaborations with the materials science community, and through increased availability of instrumentation, particularly synchrotron sources. The ability to understand not only the biopharmaceutical outcome, but also arguably, more importantly, the structural aspects of drugs and drug delivery systems, is essential to progressing pharmaceutical science; this review serves as an introduction to the major techniques and the wide range of areas in which X-ray scattering may be applied in understanding and controlling structure in pharmaceutical systems.
X 射线散射技术在药物科学中的应用正在增加，部分原因是与材料科学领域的合作增加，以及仪器设备，特别是同步加速器源的可用性增加。不仅要能够理解生物制药的结果，而且可以说更重要的是，要理解药物和药物输送系统的结构方面，这对于推进药物科学至关重要；本文综述了主要技术以及 X 射线散射在理解和控制药物系统结构方面可能应用的广泛领域。
