小鼠乳腺肿瘤病毒与低乳腺肿瘤小鼠品系中自发和激素诱导的乳腺肿瘤的关系。
Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains.
作者信息
Michalides R, van Deemter L, Nusse R, Röpcke G, Boot L
出版信息
J Virol. 1978 Sep;27(3):551-9. doi: 10.1128/JVI.27.3.551-559.1978.
Abstract
The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained. (i) Mammary tumors which appeared in C3H mice as a result of an infection with MTV contained more MTV DNA compared with noninfected organs; these mammary tumors also contained more MTV RNA than was present in lactating mammary gland cells. (ii) Hormonal stimulation by administration of excessive amounts of prolactin via hypophyseal isografts in C3Hf and O20 mice resulted in an increased expression of MTV RNA in the mammary glands. This elevated level of MTV RNA expression was, however, not maintained in the hormone-induced mammary tumors. (iii) Spontaneous mammary tumors in BALB/c mice contained similar levels of MTV DNA and MTV RNA sequences as were found in other cells of these animals.
摘要
通过比较经激素处理和未经激素处理的小鼠乳腺肿瘤及其他组织中鼠乳腺肿瘤病毒（MTV）RNA和MTV DNA序列的含量，研究了MTV在低乳腺肿瘤小鼠品系的自发性和激素诱导性乳腺肿瘤中的作用。获得了以下结果。（i）因感染MTV而在C3H小鼠中出现的乳腺肿瘤，与未感染的器官相比，含有更多的MTV DNA；这些乳腺肿瘤所含的MTV RNA也比泌乳乳腺细胞中的多。（ii）通过在C3Hf和O20小鼠中经垂体同基因移植给予过量催乳素进行激素刺激，导致乳腺中MTV RNA表达增加。然而，这种MTV RNA表达的升高水平在激素诱导的乳腺肿瘤中并未维持。（iii）BALB/c小鼠的自发性乳腺肿瘤所含的MTV DNA和MTV RNA序列水平与这些动物的其他细胞中发现的相似。
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本文引用的文献
1
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Cancer Res. 1959 May;19(4):402-12.
2
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
3
Studies on hypophyseal isografts in mice. I. Biologic aspects.小鼠垂体同基因移植研究。I.生物学方面。
Cancer Res. 1966 Jul;26(7):1492-6.
4
Note on a new inbred mouse-strain GR-A.关于一种新的近交系小鼠品系GR-A的说明。
Eur J Cancer (1965). 1965 Oct;1(2):123-4. doi: 10.1016/0014-2964(65)90003-4.
5
Analysis of repeating DNA sequences by reassociation.通过重缔合分析重复DNA序列。
Methods Enzymol. 1974;29:363-418. doi: 10.1016/0076-6879(74)29033-5.
6
Kinetic complexity of RNA molecules.RNA分子的动力学复杂性。
J Mol Biol. 1972 Jan 14;63(1):21-39. doi: 10.1016/0022-2836(72)90519-0.
7
Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.高肿瘤发生率和低肿瘤发生率小鼠品系组织中小鼠乳腺肿瘤病毒基因的转录
J Mol Biol. 1973 Oct 5;79(4):663-79. doi: 10.1016/0022-2836(73)90070-3.
8
The biology of the mouse mammary tumor virus.小鼠乳腺肿瘤病毒的生物学
Int Rev Exp Pathol. 1972;11:259-97.
9
Interactions between viral and genetic factors in the origin of mammary tumors in mice.小鼠乳腺肿瘤起源中病毒与遗传因素之间的相互作用。
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J Natl Cancer Inst. 1974 Jun;52(6):1881-6. doi: 10.1093/jnci/52.6.1881.
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